实用医学杂志2026，Vol.42Issue(9)：1610-1616,7.DOI:10.3969/j.issn.1006-5725.2026.09.016
BMP-2、Galectin-3、COMP水平对老年2型糖尿病合并骨关节炎的预测价值
The predictive value of BMP-2,Galectin-3 and COMP levels for elderly patients with type 2 diabetes mellitus complicated with osteoarthritis
摘要
Abstract
Objective To explore the high-risk factors of senile type 2 diabetes complicated with osteoarthritis,as well as the levels of bone morphogenetic protein-2(BMP-2),Galectin-3,and cartilage oligomeric matrix protein(COMP).Methods The study subjects were selected from elderly patients with type 2 diabetes who were admitted to our hospital during the enrollment period from June 2022 to June 2025.A total of 370 cases were included.Based on whether the selected patients were complicated with osteoarthritis,they were divided into the combined group(163 cases)and the non-combined group(207 cases).The clinical data,as well as the levels of BMP-2,Galectin-3,and COMP,of the two groups were compared.Multivariate Logistic regression analysis was employed to analyze the risk factors of elderly type 2 diabetes complicated with osteoarthritis.The receiver operating characteristic(ROC)curve was utilized to analyze the predictive value of serum BMP-2,Galectin-3,and COMP for elderly type 2 diabetes with osteoarthritis.Moreover,the regression equation of serum BMP-2,Galectin-3,and COMP in predicting elderly type 2 diabetes patients with osteoarthritis was constructed.The levels of BMP-2,Galectin-3,and COMP under different disease conditions were compared.Results The proportions of females,individuals with a smoking history,and those with hypertension in the combined group were higher than those in the non-combined group.The combined group was older and had a longer duration of type 2 diabetes(P＜0.05).The level of serum BMP-2 in the combined group was lower than that in the non-combined group,while the levels of serum Galectin-3 and COMP were higher than those in the non-combined group(P＜0.05).Multivariate logistic regression analysis showed that being female,having a smoking history,having hypertension,being of an older age,having a long duration of type 2 diabetes,having a low level of serum BMP-2,having a high level of serum Galectin-3,and having a high level of serum COMP were independent risk factors for elderly type 2 diabetes with osteoarthritis(OR=3.043,3.758,2.680,2.472,2.155,2.578,2.375,2.010,P＜0.05).A regression equation was constructed:logit(P)=-8.012+sex × 1.113+smoking history × 1.324+hypertension × 0.986+age × 0.905+type 2 diabetes duration × 0.768+serum BMP-2 level × 0.947+serum Galectin-3 level × 0.865+serum COMP level × 0.698.The construction of a logistic multiple regression diagnostic equation is effective.Based on the diagnostic probability logit(P),an ROC curve was plotted to predict elderly patients with type 2 diabetes and osteoarthritis.When logit(P)＞0.246,the area under the curve(AUC)value was 0.884,the 95％confidence interval(CI)was 0.847-0.915,and thex2value was 22.578.The diagnostic sensitivity and specificity were 82.21％and 80.19％,respectively.The AUC of serum BMP-2,Galectin-3,COMP,and combined detection for predicting elderly patients with type 2 diabetes and osteoarthritis were 0.793,0.721,0.792,and 0.843,respectively.The diagnostic sensitivities were 72.39％,72.39％,73.62％,and 91.41％,respectively,and the specificities were 73.91％,62.32％,77.29％,and 66.18％,respectively.The AUC of the combined detection was the highest(P＜0.05).The level of serum BMP-2 in the severe group was lower than that in the mild and moderate groups,and the level in the moderate group was lower than that in the mild group.The levels of serum Galectin-3 and COMP in the severe group were higher than those in the mild and moderate groups,and the level in the moderate group was higher than that in the mild group(P＜0.05).Conclusions Female gender,a history of smoking,hypertension,advanced age,a long duration of type 2 diabetes,a low level of serum BMP-2,a high level of serum Galectin-3,and a high level of serum COMP were identified as independent risk factors for type 2 diabetes accompanied by osteoarthritis in the elderly.Serum BMP-2,Galectin-3,and COMP were,to some extent,associated with the severity of osteoarthritis.They could be utilized for the auxiliary diagnosis of the onset of type 2 diabetes complicated by osteoarthritis in the elderly and the assessment of osteoarthritis.The combined detection of these three markers had the highest predictive value for type 2 diabetes complicated by osteoarthritis in the elderly.关键词
老年/2型糖尿病/骨关节炎/高危因素/骨形态发生蛋白-2/半乳糖凝集素-3/软骨寡聚基质蛋白Key words
old age/type 2 diabetes/osteoarthritis/high risk factors/bone morphogenetic protein-2/galectin-3/oligomeric matrix protein of cartilage分类
医药卫生引用本文复制引用
王颖,张谷月,王惠,孙素雅,王凤飞,张鸽..BMP-2、Galectin-3、COMP水平对老年2型糖尿病合并骨关节炎的预测价值[J].实用医学杂志,2026,42(9):1610-1616,7.基金项目
河北省医学科学研究课题计划项目(编号:20231789) （编号:20231789）
河北省中医药类科学研究课题计划项目(编号:2024434) （编号:2024434）
