实用中医内科杂志2026，Vol.40Issue(4)：113-117,后插28,6.DOI:10.13729/j.issn.1671-7813.Z25080804
骨性关节炎中细胞焦亡的影响及其机制
The Impact and Mechanism of Cell Pyroptosis in Osteoarthritis
摘要
Abstract
Recent studies have revealed novel forms of cell death,distinct from apoptosis and necrosis,that are induced by extreme microenvironmental factors.Pyroptosis is a regulated form of cell death that occurs when pattern recognition receptors(PRRs)induce the activation of caspase-1 or caspase-11,leading to the maturation and release of the proinflammatory cyto-kines IL-1 βand IL-1 8.Osteoarthritis(OA),the most prevalent joint disease worldwide,is characterized by mild inflamma-tion and elevated cytokine levels,including IL-1βand IL-18.Moreover,some damaged chondrocytes exhibit morphological alterations resembling pyroptosis during OA pathogenesis.This regulatory cell death process can contribute to the pathological al-terations observed in OA.This review summarizes the molecular mechanisms underlying pyroptosis and the role of the NLRP3 in-flammasome(NLR family,pyrin domain containing 3)in this process.This review aims to elucidate the role of pyroptosis in the pathogenesis of OA,highlighting its potential significance.关键词
骨关节炎/细胞焦亡/NLRP3Key words
Osteoarthritis/Pyroptosis/NLRP3 inflammasome分类
医药卫生引用本文复制引用
黄琰,张宇,郑曲,陈巍,宫云昭..骨性关节炎中细胞焦亡的影响及其机制[J].实用中医内科杂志,2026,40(4):113-117,后插28,6.基金项目
辽宁省科技计划联合计划(基金)项目(2023-MSLH-143) （基金）
辽宁省教育厅高校基本科研项目(面上项目)(LJKMZ20221327) （面上项目）
