特产研究2026，Vol.48Issue(2)：98-103,6.DOI:10.16720/j.cnki.tcyj.2024.261
苹果木栽培的牛樟芝抑制结直肠癌细胞增殖活性的研究
Research on the Inhibitory Activity of Antrodia cinnamomea Cultivated on Apple Wood Against the Proliferation of Colorectal Cancer Cells
摘要
Abstract
In order to study the inhibitory effect of Antrodia cinnamomea cultivated on apple wood on colorectal cancer cells in vivo and in vitro.The MTT method was used to detect the inhibitory rate of Antrodia cinnamomea extract on the proliferation of HT29 and HCT116 cell lines with different concentrations.The effect of the extract on the tumor growth of Antrodia cinnamomea was detected in a colorectal cancer xenograft mouse model by gavage technique.The results showed that in vitro the extracts of Antrodia cinnamomea cultivated on ap-ple wood have inhibitory effects on the proliferation of human colorectal cancer HT29 and HCT116 cells,and the half inhibition rates of the cells are(26.15±6.41)mg/L and(20.09±3.07)mg/L;In vivo the extract of Antrodia cinnamomea cultivated on apple wood can inhibit the growth of tumors in human colorectal cancer HT29 tumor-bearing mice(P＜0.05),Antrodia cinnamomea cultivated on apple wood effectively in-hibits the proliferation of human colorectal cancer cells in vitro,and the high-dose extract exhibits significantly antitumor activity in vivo,providing an experimental basis for its potential clinical application in the treatment of colorectal cancer.关键词
牛樟芝/结直肠癌/抗肿瘤Key words
Antrodia cinnamomea/colorectal cancer/antitumor分类
医药卫生引用本文复制引用
李寅,连林涛,宫文静,项金瑜,李艺,程显好,慕岳峻..苹果木栽培的牛樟芝抑制结直肠癌细胞增殖活性的研究[J].特产研究,2026,48(2):98-103,6.基金项目
山东省现代农业产业技术体系食用菌产业体系岗位专家项目(鲁农科技字[2016]18号) （鲁农科技字[2016]18号）
山东省农业重大应用技术创新项目(2017006) （2017006）
山东省中医药科技项目(M-2022040) （M-2022040）
山东省中医药科技项目(M-2023035) （M-2023035）
