同位素2026，Vol.39Issue(1)：58-71,14.DOI:10.7538/tws.2025.youxian.039
硼中子俘获疗法的核心:从分子设计到临床转化的含硼药物研究进展
Advances in Boron Neutron Capture Therapy(BNCT):From Boron-Containing Drug Design to Clinical Translation
摘要
Abstract
Boron Neutron Capture Therapy(BNCT)is a binary targeted radiotherapy technique that combines biological and physical targeting.Its core principle lies in the delivery of boron-10(10B)to tumor sites via tumor-specific carriers,followed by thermal neutron irradiation.This triggers the 10B(n,α)7Li nuclear reaction,generating high linear energy transfer particles(alpha particles and 7Li ions)that precisely destroy cancer cells.With advancements in key facilities such as neutron sources,significant progress has been made in the innovative design and clinical translation of boron-containing drugs,which are central to BNCT efficacy.This article systematically reviews the evolution of three generations of boron carriers,from nontargeted small molecules to intelligent delivery systems.It focuses on analyzing the molecular design strategies and targeting advantages of third-generation agents—including targeted amino acid/sugar derivatives,nanocarriers,and antibody-drug conjugates—and summarizes key outcomes from global BNCT clinical trials.Although challenges remain,such as precise monitoring of intratumoral boron concentration and the establishment of standardized treatment protocols,BNCT demonstrates considerable potential as a promising modality for treating refractory solid tumors through continued interdisciplinary collaboration.关键词
硼中子俘获疗法/硼-10富集/含硼药物/肿瘤靶向性/小分子含硼药物Key words
boron neutron capture therapy/10B enrichment/boron carrier/tumor targeting/small-molecule boron drug分类
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叶炳权,杨忠道,童永彭,关东,袁国涛,张平玉..硼中子俘获疗法的核心:从分子设计到临床转化的含硼药物研究进展[J].同位素,2026,39(1):58-71,14.基金项目
中核领创科研项目(CNNC-LCKY-202269) （CNNC-LCKY-202269）
国家自然科学基金(22477080) （22477080）
广东省自然科学基金(2023B1515020060) （2023B1515020060）
深圳市科学技术基金(JCYJ20220531103405012,RCYX20221008092906021) （JCYJ20220531103405012,RCYX20221008092906021）
