同位素2026，Vol.39Issue(2)：158-165,8.DOI:10.7538/tws.2026.youxian.018
反载体法协同电化学法制备药用级钇-90
Preparation of Pharmaceutical-Grade Yttrium-90 Using Hold-back Carrier Method Coupled with Electrochemical Method
摘要
Abstract
To address the technical challenge that traditional electrochemical methods face in balancing high 90Y recovery with low 90Sr residue during the separation of 90Sr/90Y,this study proposes for the first time the combination of the hold-back carrier method with electrochemistry.By introducing non-radioactive Sr as a hold-back carrier,the 90Sr content in 90Y was reduced to below 1×10-6 Bq 90Sr/Bq 90Y,while maintaining a 90Y recovery rate of over 80%.The effects of electrolyte pH,electrolysis voltage,electrolysis time,and the hold-back carrier Sr on the recovery of 90Y and the residue of 90Sr were systematically investigated.It is confirmed that the electrolysis voltage is the key factor affecting 90Y recovery,and the addition of hold-back carrier Sr can lower the 90Sr residue by more than one order of magnitude.Under optimized conditions(electrolyte pH=3,electrolysis voltage of 4 V,single-cycle electrolysis duration of 1 h),after two electrolysis cycles with the hold-back carrier Sr introduced in the second cycle,810 mCi of 90Y is obtained from 1 Ci of 90Sr/90Y feed material,achieving a 90Y recovery yield of 81%and a 90Sr content in 90Y was 3.1×10-7 Bq 90Sr/Bq 90Y.The 90Y product meets pharmaceutical-grade requirements in terms of radionuclide purity,radiochemical purity,and chemical impurities.关键词
90Sr/90Y分离/电化学法/反载体法/90Y回收率/90Sr残留率Key words
90Sr/90Y separation/electrochemical method/hold-back carrier method/90Y recovery/90Sr residue分类
能源科技引用本文复制引用
汤兴艳,曾松柏,李燕君,任彬,雷嗣烦,贺文明..反载体法协同电化学法制备药用级钇-90[J].同位素,2026,39(2):158-165,8.基金项目
中核集团"青年英才"项目 （）
