武汉工程大学学报2026，Vol.48Issue(2)：140-148,9.DOI:10.19843/j.cnki.CN42-1779/TQ.202409012
环糊精在制药技术中的应用
Application of cyclodextrins in pharmaceutical technology
摘要
Abstract
Poor aqueous solubility of many drug candidates leads to low bioavailability,which is an obstacle to the development of new drugs.In this review,firstly,the purification and isolation of cyclodextrins from natural products were described.Due to their high safety,cyclodextrins are widely applied in the pharmaceutical industry.Secondly,the unique structure of cyclodextrins was described,which featured a hydrophobic interior and hydrophilic exterior.Inclusion complexes could be formed between cyclodextrins and insoluble guests through host-guest interactions,resulting in improved stability,solubility and bioavailability for the guests with unchanged molecular structures.In addition,various preparation methods were discussed according to the properties of drugs,highlighting their respective scopes,advantages and limitations.Lastly,the latest applications of cyclodextrins in the pharmaceutical field were summarized,along with their pharmacokinetic and toxicology data.关键词
环糊精/包合物/溶解度/稳定性/主客体作用Key words
cyclodextrin/inclusion complex/solubility/stability/host-guest interaction分类
医药卫生引用本文复制引用
陈思雨,刘慧..环糊精在制药技术中的应用[J].武汉工程大学学报,2026,48(2):140-148,9.基金项目
武汉工程大学研究生教育创新基金(CX2023032) （CX2023032）
