无机材料学报2026，Vol.41Issue(4)：527-535,中插11-中插12,11.DOI:10.15541/jim20250165
Fe掺杂Ti-MOFs用于牙周炎抗菌声动力治疗
Fe Doped Ti-MOFs for Enhanced Antibacterial Sonodynamic Therapy of Periodontitis
摘要
Abstract
Periodontitis is a clinical challenge caused by bacterial overgrowth,resulting in irreversible damage to periodontal tissue.Antibacterial sonodynamic therapy(aSDT)has emerged as a promising alternative to conventional debridement due to its excellent biocompatibility and tissue penetration capability.However,this therapy cannot cure the periodontitis solely,needing more exploration to find an effectively improved treatment.Here,Fe doped Ti based metal-organic frameworks(Fe/Ti-MOFs)were prepared to explore the relationship between Fe doping and sonoresponsive efficiency.Incorporation of Fe enabled precise modulation of the band structure and crystallinity while maintaining the lattice architecture.Results showed that Fe/Ti-MOFs exhibited enhanced hydroxyl radical(·OH)generation under ultrasonic irradiation,effectively facilitating the eradication of bacterial pathogens.Notably,the sample with a Fe/Ti molar ratio of 0.025:1 exhibited exceptional performance.The sonocatalytic activity was collectively influenced by bandgap engineering,Fe doping concentration and crystallinity.Moreover,Fe/Ti-MOFs exhibited no cytotoxicity toward gingival fibroblasts and maintained excellent biocompatibility,without adverse effects on tissue repair.The ultrasound responsive Fe/Ti-MOFs material developed in this study offers potential for mitigating the adverse effects of antibiotics and providing novel insights and strategies for the application of aSDT in periodontitis treatment.关键词
抗菌/声动力治疗/牙周炎/金属有机框架/NH2-MIL-125(Ti)Key words
antibacterial/sonodynamic therapy/periodontitis/metal organic framework/NH2-MIL-125(Ti)分类
医药卫生引用本文复制引用
王浩宇,柯学,关世伟,钱仕,刘宣勇..Fe掺杂Ti-MOFs用于牙周炎抗菌声动力治疗[J].无机材料学报,2026,41(4):527-535,中插11-中插12,11.基金项目
National Natural Science Foundation of China(52450110) （52450110）
