现代妇产科进展2026，Vol.35Issue(4)：272-276,5.DOI:10.13283/j.cnki.xdfckjz.2026.04.006
Hcy、凝血指标与不良妊娠的关系及对再次妊娠结局的预测价值
The relationship between Hcy、coagulation indexes and adverse pregnancy and its predic-tive value for the outcome of second pregnancy
摘要
Abstract
Objective:To explore the correlation between homocysteine(Hcy),coagula-tion indicators and adverse pregnancy outcomes and the predictive value of pregnancy out-comes.Methods:A total of 182 patients with second pregnancy admitted to our hospital from June 2021 to June 2025 were selected as the research object,and they were divided into a good pregnancy group(120 cases)and an adverse pregnancy group(62 cases)according to the sec-ond pregnancy outcome.The adverse outcome of second pregnancy was analyzed by univariate analysis and binary logistic regression analysis,and the area under the ROC curve was used to evaluate the predictive efficacy of Hcy and coagulation indicators on the model.Results:The prothrombin time(PT)and thromboplastin time(APTT)in the poor pregnancy group were low-er than those in the good pregnancy group,while the positive rates of Hcy,D-Dimer(D-D),fi-brinogen(FIB)and lupus anticoagulant(LA)were higher than those in the good pregnancy group(P<0.05).Multivariate regression showed that Hcy,D-D,FIB and LA were independent predictors of adverse outcomes of second pregnancy.The area under the curve(AUC)was 0.842(95%CI:0.766～0.908),0.862(95%CI:0.803～0.921),0.735(95%CI:0.660～0.809),0.644(95%CI:0.554～0.734),0.971(95%CI:0.942～1.000),respectively.When the cut-off value was taken,the sensitivity was 0.758,0.710,0.694,0.933,0.942,and the specificity was 0.783,0.925,0.683,0.355,0.935,respectively.Conclusion:Hcy,D-D,FIB,LA are all independent risk factors for adverse outcomes of second pregnancy,which have a certain reference value for predicting adverse outcomes of second pregnancy.关键词
同型半胱氨酸/凝血指标/不良妊娠/再次妊娠结局/预测价值Key words
Homocysteine/Coagulation index/Adverse pregnancy/Re pregnancy out-comes/Predictive value分类
医药卫生引用本文复制引用
张镛镛,王彦秋,王瑞芳..Hcy、凝血指标与不良妊娠的关系及对再次妊娠结局的预测价值[J].现代妇产科进展,2026,35(4):272-276,5.基金项目
2021年度河南省医学科技攻关计划联合共建项目(No:LHGJ20210595) （No:LHGJ20210595）
