现代医药卫生2026，Vol.42Issue(4)：721-726,731,7.DOI:10.3969/j.issn.1009-5519.2026.04.001
代谢相关脂肪性肝病合并2型糖尿病的流行病学、机制与治疗进展
Epidemiology,mechanisms,and treatment advances of metabolic dysfunction-associated fatty liver disease comorbid with type 2 diabetes mellitus
摘要
Abstract
Metabolic dysfunction-associated fatty liver disease(MAFLD)and type 2 diabetes mellitus(T2DM)are closely linked in terms of epidemiology and pathophysiological mechanisms,and their comorbidi-ty has become a major global public health challenge.This review systematically summarized the epidemiolog-ical characteristics,core pathophysiological mechanisms,and comprehensive management strategies for the co-morbidity of MAFLD and T2DM.Global data show that the comorbid prevalence of T2DM in patients with MAFLD has risen to 34.1%,while the prevalence of MAFLD in patients with T2DM has reached 68.8%,and these rates continue to increase.The comorbidity significantly increases the risks of liver fibrosis,hepatocellu-lar carcinoma,and cardiovascular events,leading to elevated all-cause mortality.The core mechanisms revolve around insulin resistance and involve multiple factors,including lipid metabolism disorders,chronic inflamma-tion and oxidative stress,gut microbiota dysbiosis,and genetic susceptibility,forming a complex pathogenic network.In terms of treatment,lifestyle intervention serves as the foundation.Glucose-lowering agents such as glucagon-like peptide-1 receptor agonists,pioglitazone,and sodium-glucose cotransporter-2 inhibitors have demonstrated dual benefits.Statins and vitamin E also possess important potential dual-effect therapeutic val-ue.Bariatric surgery is applicable to selected obese patients.This review provided a reference for an in-depth understanding of the complexity of MAFLD complicated with T2DM and for the development of comprehen-sive prevention and treatment strategies.关键词
代谢相关脂肪性肝病/2型糖尿病/胰岛素抵抗/共病流行病学/治疗策略Key words
Metabolic dysfunction-associated fatty liver disease/Type 2 diabetes mellitus/Insulin resistance/Co-morbidity epidemiology/Therapeutic strategies分类
医药卫生引用本文复制引用
徐诗杰,刘昌赫,甘昌培,柴进..代谢相关脂肪性肝病合并2型糖尿病的流行病学、机制与治疗进展[J].现代医药卫生,2026,42(4):721-726,731,7.基金项目
国家自然科学基金项目(92268110) （92268110）
重庆市博士后研究项目特别资助(2024CQBSHTB3018). （2024CQBSHTB3018）
