畜牧与兽医2026，Vol.58Issue(5)：137-144,8.
多形性腺瘤样基因1在畜禽生长发育中的研究进展
Advances in studies on the PLAG1 gene in livestock and poultry growth and development
摘要
Abstract
The advancement of animal genomics has progressively established the zinc-finger transcription factor PLAG1(pleomorphic ade-noma gene 1)as a central regulator in early growth and body size determination in animals.This review systematically elucidates the biologi-cal significance of this gene from three key dimensions.Firstly,it focuses on clarifying the molecular basis by which PLAG1,as a nuclear transcription factor,regulates cell proliferation,differentiation,and apoptosis through promoter-specific binding.Subsequently,it evaluates the association strength between its genetic variants—including single nucleotide polymorphism(SNP),insertions/deletion(InDel),and copy number variation(CNV)—and growth traits in livestock and poultry,along with delineating the practical boundaries for their applica-tion in breeding programs.Finally,it constructs a transcriptional regulatory network orchestrated by PLAG1,revealing its dynamic mechanism in coordinating skeletal muscle development through multi-level cascade pathways.These findings not only deepen our under-standing of the principles governing muscle development in domestic animals but,more importantly,provide actionable molecular targets for precision breeding.关键词
多形性腺瘤样基因1/畜禽/生长发育Key words
PLAG1 gene/livestock and poultry/growth and development分类
农业科技引用本文复制引用
魏亚丽,房华,王永飞,董宇,李舜,林正辉,托合提麦麦提·努日,张云峰..多形性腺瘤样基因1在畜禽生长发育中的研究进展[J].畜牧与兽医,2026,58(5):137-144,8.基金项目
兵团科技计划项目(2024CC006) （2024CC006）
新疆农垦科学院青年基金项目(2025YJQN19) （2025YJQN19）
新疆农垦科学院农业科技创新工程项目(NCG202313) （NCG202313）
