湖北科技学院学报（医学版）2026，Vol.40Issue(2)：99-104,114,7.DOI:10.16751/j.cnki.2095-4646.2025090111
补阳还五汤改善糖尿病大鼠痛觉阈值的机制探讨
Discussion on the Mechanism of Buyang Huanwu Decoction in Improving the Pain Threshold of Rats with Diabetic Mellitus
摘要
Abstract
Objective To explore the pharmacological basis and mechanism of action of Buyang Huanwu Decoction in improving the pain threshold of diabetes mellitus(DM).Methods Firstly,the effect of Buyang Huanwu Decoction on the pain threshold of DM model rats was observed.Then,network pharmacology and molecular docking techniques were used to screen the potential active components and key targets of the decoction in improving the pain threshold of DM.Results Buyang Huanwu Decoction could increase the body weight of DM rats,lower their blood glucose levels,and significantly enhance the pain threshold.A total of 104 active components of the decoction for pre-venting diabetic foot(DF)were screened,among which quercetin,kaempferol,and stigmasterol were the core active components.A total of 18 important targets were screened,and the first five key targets were IL6,IL1B,TNF,STAT3 and AKT1.Molecular docking indicated that the binding energies of quercetin,kaempferol and TNF,stigmasterol and IL6,and quercetin and IL1B were all lower than-5 kcal/mol,sug-gesting good binding activity.Conclusion Buyang Huanwu Decoction can effectively increase the mechanical and thermal pain thresholds of DM rats,providing new experimental evidence for explaining the comprehensive pharmacological mechanism of the formula in preventing DF pain thresholds through a"multi-component,multi-target"approach.关键词
糖尿病/痛觉阈值/补阳还五汤/网络药理学Key words
Diabete mellitus/Pain threshold/Buyang Huanwu Decoction/Network pharmacology分类
医药卫生引用本文复制引用
洪思博,张丽君,卯明艳..补阳还五汤改善糖尿病大鼠痛觉阈值的机制探讨[J].湖北科技学院学报（医学版）,2026,40(2):99-104,114,7.基金项目
湖北省重点研发计划大健康领域支持地方专项(2022BCE051) （2022BCE051）
湖北省自然科学基金计划(2023AFB455) （2023AFB455）
湖北省大学生创新创业训练计划项目(S202310927019) （S202310927019）
