信阳师范大学学报（自然科学版）2026，Vol.39Issue(2)：292-298,7.DOI:10.3969/j.issn.2097-583X.2026.02.017
调控猪骨骼肌卫星细胞分化关键lncRNAs鉴定及功能研究
Identification and functional study of key lncRNAs regulating the differentiation of porcine skeletal muscle satellite cells
摘要
Abstract
The development of porcine skeletal muscle can directly affect the economic benefits of the livestock industry.Aiming at the problem of porcine skeletal muscle development,the regulatory role of key lncRNAs was explored in the myogenic differentiation of porcine skeletal muscle satellite cells.The RNA-Seq method was used to construct the transcriptional atlas of porcine skeletal muscle satellite cells.The results showed that:3849 genes were differentially expressed in skeletal muscle cells at different differentiation stages,among which 3557 were mRNAs and 292 were lncRNAs;These differentially expressed genes were significantly enriched in biological processes and pathways such as axon guidance and arrhythmogenic right ventricular cardiomyopathy;Three candidate lncRNAs(MSTRG.13015,MSTRG.7609,MSTRG.18703)might play important regulatory functions during the differentiation of porcine skeletal muscle satellite cells.MSTRG.13015 had a relatively high expression level at 60 hours of porcine skeletal muscle satellite cell differentiation.MSTRG.7609 had relatively higher expression levels at 0 hours and 48 hours of differentiation compared with that at 60 hours of differentiation.The expression level of MSTRG.18703 was relatively higher than that of the previous two lncRNAs and continued to increase with the increase of differentiation time.关键词
猪/lncRNAs/RNA-seq/鉴定/骨骼肌卫星细胞Key words
pig/lncRNAs/RNA-seq/identification/skeletal muscle satellite cells分类
农业科技引用本文复制引用
李岑岑,李甜宇,杨悦悦,解秀杰,王剑锋,张朋朋,徐永杰,程晓芳..调控猪骨骼肌卫星细胞分化关键lncRNAs鉴定及功能研究[J].信阳师范大学学报（自然科学版）,2026,39(2):292-298,7.基金项目
国家自然科学基金青年项目(32202654) （32202654）
河南省自然科学基金项目(212300410230) （212300410230）
信阳师范学院高层次人才科研启动基金项目(18155) （18155）
