新医学2026，Vol.57Issue(4)：422-430,9.DOI:10.12464/j.issn.0253-9802.2025-0317
竞争性内源性RNA网络在慢性肾衰竭中的作用及中医药干预研究进展
Roles of the competitive endogenous RNA network in chronic renal failure and research progress in traditional Chinese medicine interventions
摘要
Abstract
Chronic renal failure(CRF)is associated with multiple complications,a poor prognosis,and limited therapeutic options.Recent studies have shown that the competitive endogenous RNA(ceRNA)network mediated by long non-coding RNAs(lncRNAs)and circular RNAs is widely involved in pathological processes of CRF,such as inflammation activation,oxidative stress,apoptosis,renal fibrosis,extracellular matrix component and structural remodeling,and ferroptosis.It mediates the formation of the pathological loop of"inflammation-injury-fibrosis"during the progression of CRF,thus making it a potential therapeutic target.However,most current studies focus on a single ceRNA axis and lack systematic analysis of the central nodes and dynamic regulatory mechanisms of the network.This article reviews the mechanism of the ceRNA network in CRF and analyzes the intervention effect of traditional Chinese medicine(TCM)on key targets of the ceRNA network,providing a new perspective for interpreting the effects of TCM from the perspective of molecular biology.The"multi-component,multi-target"characteristic of TCM is highly consistent with the complexity of the ceRNA network.TCM can effectively delay the occurrence and development of CRF through multiple pathways,such as anti-inflammation,anti-renal fibrosis,improving cell injury and apoptosis,and reducing extracellular matrix deposition.关键词
慢性肾衰竭/中医药/竞争性内源性RNA 网络/长链非编码RNA/环状RNAKey words
Chronic renal failure/Traditional Chinese medicine/Competitive endogenous RNA network/Long non-coding RNA/Circular RNA引用本文复制引用
李嘉源,钟建,杜谋英,吕沁珂,石晓冬..竞争性内源性RNA网络在慢性肾衰竭中的作用及中医药干预研究进展[J].新医学,2026,57(4):422-430,9.基金项目
国家自然科学基金(82260866) （82260866）
广西自然科学基金(2022JJA140201) （2022JJA140201）
