疑难病杂志2026，Vol.25Issue(4)：496-500,507,6.DOI:10.3969/j.issn.1671-6450.2026.04.021
钙化性主动脉瓣疾病的分子致病机制及其药物治疗研究进展
Research progress on molecular pathogenic mechanisms and drug therapy of calcific aortic valve disease
摘要
Abstract
Calcific aortic valve disease(CAVD)has become one of the most common heart valve diseases worldwide,with a significantly increased incidence among the elderly.The pathological features of this disease include progressive fibrosis and calcium salt deposition in the aortic valve leaflets,leading to valve thickening,hardening,and eventually aortic stenosis,which seriously affects cardiac function and increases the risk of cardiovascular events.In recent years,with the rapid develop-ment of molecular biology,imaging,and other fields,significant progress has been made in the study of its pathogenesis,re-vealing that this disease is not a simple degenerative lesion but an active,complex,and controllable pathological process invol-ving multiple molecular and cellular pathways.This review aims to systematically summarize the research progress in the epi-demiology,pathogenesis,and treatment strategies of calcific aortic valve disease,focusing on the roles of key factors such as inflammatory response and lipid metabolism abnormalities in the disease's occurrence and development,and to look forward to the limitations of current research and future directions,with the aim of providing a theoretical basis for early diagnosis,precise intervention,and new drug development.关键词
钙化性主动脉瓣疾病/流行病学/分子致病机制/药物治疗Key words
Calcific aortic valve disease/Epidemiology/Molecular pathogenic mechanism/Drug treatment分类
医药卫生引用本文复制引用
李昭倩,赵海,安利钦,马艳侠..钙化性主动脉瓣疾病的分子致病机制及其药物治疗研究进展[J].疑难病杂志,2026,25(4):496-500,507,6.基金项目
国家自然科学基金青年科学基金项目(82400441) （82400441）
陕西省科技厅一般项目(青年)(2023-JC-QN-0848) National Natural Science Foundation of China,Youth Science Foundation Project(82400441) （青年）
General Project of Shaanxi Provincial Department of Science and Technology(Youth)(2023-JC-QN-0848) （Youth）
