疑难病杂志2026，Vol.25Issue(4)：501-507,7.DOI:10.3969/j.issn.1671-6450.2026.04.022
中性粒细胞胞外诱捕网在急性肾损伤中的作用及潜在机制研究进展
The role and potential mechanisms of neutrophil extracellular traps in acute kidney injury
摘要
Abstract
Neutrophil activation can release neutrophil extracellular traps(NETs),which are involved in capturing and killing pathogenic microorganisms,as well as maintaining the body's immune balance.In pathological conditions,excessive release of NETs can promote inflammation and fibrosis in various organs,and contribute to the occurrence and development of various diseases,including acute kidney injury(AKI).Studies have confirmed that NETs can participate in the pathogenesis of AKI by regulating oxidative stress,inflammatory responses including inflammatory response,pyroptosis,Nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB)、Signal transducers and activators of transcription(STAT),as well as fibrosis processes such as transforming growth factor β1 signaling.Transforming growth factor-beta 1(TGF-β1)and other pathways.NETs play an important pathogenic role in the initiation and progression of AKI.Therefore,the activation of NETs may be a new mechanism and potential intervention target affecting the occurrence and development of AKI.In this review,we summa-rize the formation of NETs,their biological roles and the underlying molecular mechanisms in AKI.关键词
中性粒细胞胞外诱捕网/急性肾损伤/炎性反应/纤维化/作用机制Key words
Neutrophil extracellular traps/Acute kidney injury/Inflammation/Fibrosis/Mechanism分类
医药卫生引用本文复制引用
钱靖榕,张琦,唐静,刘其锋..中性粒细胞胞外诱捕网在急性肾损伤中的作用及潜在机制研究进展[J].疑难病杂志,2026,25(4):501-507,7.基金项目
江苏省卫生健康委2023年度医学科研立项项目(Z2023039) （Z2023039）
2025年度苏州市科技攻关计划(医疗卫生创新)项目(SYW2025071) （医疗卫生创新）
江苏大学医教协同创新基金研究项目(JDY2023016) Medical Research Project,Jiangsu Provincial Health Commission(Z2023039) （JDY2023016）
2025 Suzhou Science and Technology Key Research Program(Medical and Health Innovation Project(SYW2025071) （Medical and Health Innovation Project(SYW2025071）
Medical Education Collaborative Innovation Fund,Jiangsu University(JDY2023016) （JDY2023016）
