烟台大学学报（自然科学与工程版）2026，Vol.39Issue(2)：160-169,10.DOI:10.13951/j.cnki.37-1213/n.240801
罗替戈汀山嵛酸酯对帕金森抑郁症大鼠的治疗作用
Therapeutic Effect of Rotigotine Behenate on Parkinson's Depression Rats
摘要
Abstract
This experiment aims to explore the therapeutic effect of Rotigotine Behenate(ROTB)on depression in Parkinson's disease(DPD)rats.Rotigotine concentrations in rat plasma were determined by liquid chromatogra-phy-tandem mass spectrometry(LC-MS/MS).DPD rats were induced using 6-OHDA and CUMS and treated with ROTB at a doses of 5.6,11.2 and 22.4 mg/kg.The antidepressant effect of ROTB in DPD rats was assessed using forced swimming,open field,and sucrose preference tests.Expression levels of BDNF,TrkB,PI3K,Akt,p-Akt,GSK-3β and p-GSK-3β were measured by Western blot,while DA and 5-HT contents in the prefrontal cortex were analyzed by ELISA.Pathological changes in neurons in the prefrontal cortex were observed using HE staining.The results showed that a single intramuscular injection of ROTB enabled continuous and stable release of rotigotine for 28 days.ROTB alleviated depressive symptoms in DPD rats,potentially by up-regulating DA and 5-HT levels,enhancing the BDNF-TrkB and PI3K-Akt-GSK-3β signaling pathways,and reducing neuronal damage in the prefrontal cortex.These findings suggest that ROTB has therapeutic potential for treating depression in DPD rats.关键词
罗替戈汀山嵛酸酯/帕金森病抑郁/6-羟基多巴胺/慢性不可预知温和应激Key words
Rotigotine Behenate/depression in Parkinson's disease/6-hydroxydopamine/chronic unpredictable mild stress分类
医药卫生引用本文复制引用
尹智聪,陈雨萌,张红,沙春洁,于昕..罗替戈汀山嵛酸酯对帕金森抑郁症大鼠的治疗作用[J].烟台大学学报（自然科学与工程版）,2026,39(2):160-169,10.基金项目
山东省自然科学基金资助项目(ZR2020MH377). （ZR2020MH377）
