空军军医大学学报2026，Vol.47Issue(4)：559-564,6.DOI:10.13276/j.issn.2097-1656.2026.04.013
基于文献计量法的食管癌免疫治疗研究热点的可视化分析
Visual analysis of research hotspots in immunotherapy for esophageal cancer based on bibliometric methods
摘要
Abstract
Objective To conduct a visualization analysis of the research status,development trends,and hot topics in the field of esophageal cancer immunotherapy over the past decade,aiming to help researchers systematically understand research dynamics in this field.Methods We retrieved relevant publications on esophageal cancer immunotherapy from the Web of Science Core Collection published between January 2014 and October 2024.Using VOSviewer 1.6.17 and CiteSpace 6.2.R3,we performed visualization analysis of countries,authors,institutions,journals,citations,and keywords to identify research hotspots and evolutionary trends.Results A total of 836 articles were included,showing a continuous growth in annual publications.The most prolific author was PIESSEN G;the top three countries by publication volume were China,the United States,and France;key research institutions included Zhengzhou University,Tongji University,and Université de Lille.The top three journals by citation frequency were Clinical Cancer Research,Frontiers in Immunology,and International Journal of Radiation Oncology Biology Physics;the most cited article was"PD-L1 expression in human cancers and its association with clinical outcomes"by WANG X et al.High-frequency keywords included esophageal squamous cell carcinoma,survival,tumor microenvironment,and clinical trials.Research hotspots focused on the comprehensive efficacy of immunotherapy combined with radiochemotherapy,related clinical trials,and mechanisms of the tumor microenvironment.Conclusion Current research trends in esophageal cancer immunotherapy focus on exploring pathways to enhance efficacy,optimizing combination treatment regimens,and investigating the interaction mechanisms between the tumor microenvironment and immunotherapy.关键词
食管肿瘤/免疫疗法/文献计量学/数据可视化/肿瘤微环境/联合治疗方式/临床试验/放化疗Key words
esophageal neoplasms/immunotherapy/bibliometrics/data visualization/tumor microenvironment/combined modality therapy/clinical trials/chemoradiotherapy分类
医药卫生引用本文复制引用
高艳,马晓丽,魏瑜,曹雷雨,渠成程,张莉..基于文献计量法的食管癌免疫治疗研究热点的可视化分析[J].空军军医大学学报,2026,47(4):559-564,6.基金项目
新疆维吾尔自治区卫生健康保健科研专项(BL202419) （BL202419）
新疆维吾尔自治区天山英才医药卫生高层次领军人才培养项目(TSYC202401A001) （TSYC202401A001）
新疆医科大学第一附属医院"青年科研启航"专项基金青年项目(2022YFY-QKQN-14) （2022YFY-QKQN-14）
