空军军医大学学报2026，Vol.47Issue(4)：589-593,5.DOI:10.13276/j.issn.2097-1656.2026.04.017
结直肠癌患者外周血中性粒细胞与淋巴细胞比值、D-二聚体、癌胚抗原、糖类抗原19-9和糖类抗原72-4单一及联合检测的临床意义
Clinical significance of single and combined detection of neutrophil-to-lymphocyte ratio,D-dimer,carcinoembryonic antigen,carbohydrate antigen 19-9,and carbohydrate antigen 72-4 in peripheral blood of patients with colorectal cancer
摘要
Abstract
Objective To evaluate the clinical value of single and combined detection of neutrophil-to-lymphocyte ratio(NLR),D-dimer(DD),carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),and carbohydrate antigen 72-4(CA72-4)in peripheral blood for the diagnosis of colorectal cancer(CRC).Methods The study was conducted at Jilin People's Hospital from January to December 2024.The observation group consisted of 102 CRC patients diagnosed by pathology during this period,while the control group included 51 healthy individuals who underwent health check-ups during the same period.Peripheral blood samples were collected to measure NLR,DD,CEA,CA19-9,and CA72-4 levels.Differences in these indicators between the two groups were compared.Positive rates were calculated for individual markers and for conventional combined detection(defined as positivity if any one of NLR,DD,CEA,or CA19-9 exceeded the conventional reference threshold).The diagnostic performance of each individual and combined indicator was assessed using receiver operating characteristic(ROC)curve analysis,and a weighted combined diagnostic model was constructed by binary logistic regression.Results The levels of NLR,DD,CEA,and CA19-9 in the control group were significantly lower than those in the observation group(all P<0.05),while the difference in CA72-4 levels between the two groups was not significant.The positive rate of conventional combined detection(any of NLR,DD,CEA,or CA19-9 positive)was 90.20%(92/102),significantly higher than that of any single marker(all P<0.05).ROC curve analysis revealed that the areas under the curve(AUCs)for NLR,DD,CEA,and CA19-9 alone were 0.827,0.750,0.843,and 0.630,respectively.The weighted combined diagnostic model achieved an AUC of 0.924[(95%CI(0.883,0.966)],with a sensitivity of 87.3%and a specificity of 84.3%.Its diagnostic performance was significantly superior to that of any single marker(all P<0.01).Conclusion NLR,DD,CEA,and CA19-9 are effective auxiliary diagnostic indicators for CRC.The weighted combined diagnostic model based on binary logistic regression demonstrates high diagnostic accuracy and may serve as a useful tool in clinical auxiliary diagnosis.CA72-4 showed limited diagnostic value in this cohort.关键词
结直肠肿瘤/癌胚抗原/糖类抗原19-9/中性粒细胞与淋巴细胞比值/D-二聚体/糖类抗原72-4/联合检测/诊断效能Key words
colorectal neoplasms/carcinoembryonic antigen/carbohydrate antigen 19-9/neutrophil-to-lymphocyte ratio/D-dimer/carbohydrate antigen 72-4/combined detection/diagnostic performance分类
医药卫生引用本文复制引用
迟艳新,祝宏伟,齐菲,赵伟..结直肠癌患者外周血中性粒细胞与淋巴细胞比值、D-二聚体、癌胚抗原、糖类抗原19-9和糖类抗原72-4单一及联合检测的临床意义[J].空军军医大学学报,2026,47(4):589-593,5.基金项目
吉林市科技创新发展计划项目(20230406147) （20230406147）
