医药导报2026，Vol.45Issue(5)：820-828,9.DOI:10.3870/j.issn.1004-0781.2026.05.013
二氯乙酸盐在炎症性疾病中抗炎作用的研究进展
Advances in the Anti-Inflammatory Effects of Dichloroacetate in Inflammatory Diseases
摘要
Abstract
Dichloroacetate(DCA)is a pan-inhibitor of pyruvate dehydrogenase kinase(PDK).PDK inhibits the pyru-vate dehydrogenase complex(PDC),thereby promoting a shift in cellular metabolism from oxidative phosphorylation towards aero-bic glycolysis(the Warburg effect).By inhibiting PDK,DCA activates PDC,reverses aerobic glycolysis,enhances mitochondrial oxidative phosphorylation,and reduces lactate production.In recent years,with the in-depth study of the glycolytic pathway in tumors and inflammatory diseases,an increasing number of studies have revealed the potential clinical value of DCA in inflamma-tory diseases.This article reviews the research progress regarding the anti-inflammatory activity and mechanisms of DCA in various inflammatory diseases,aiming to provide references for both basic research and clinical applications of DCA in these conditions,as well as to offer new perspectives for the treatment of inflammatory diseases.关键词
二氯乙酸盐/丙酮酸脱氢酶激酶/代谢重编程/免疫调控/炎症Key words
Dichloroacetate/Pyruvate dehydrogenase kinase/Metabolic reprogramming/Immunoregulation/Inflammation分类
医药卫生引用本文复制引用
吴小欢,商敏,胡晗,刘玉娟,张萍,何秋翼,林世德..二氯乙酸盐在炎症性疾病中抗炎作用的研究进展[J].医药导报,2026,45(5):820-828,9.基金项目
国家自然科学基金资助项目(81860114). （81860114）
