摘要
Abstract
Objective To develop the Summary Table for the Rational Drug Use of Chinese Patent Medicines Containing Toxic Decoction Pieces(hereinafter referred to as the Summary Table),aiming to provide a rapid reference for clinical medication safety and to evaluate its application value preliminarily.Methods A study was conducted on Chinese patent medicines availa-ble in Xiyuan Hospital,China Academy of Chinese Medical Sciences,from April to June 2025.Data were systematically integrated from drug package inserts,the China National Knowledge Infrastructure(CNKI)database,specialized reference texts(e.g.,To-xicity and Detoxification of Chinese Medicines and Hundred Toxins Detoxification Formulas),and online user feedback.Information concerning adverse drug reactions(ADRs)/medication-related injuries associated with these medicines,potential ADRs/medi-cation-related injuries of the contained toxic decoction pieces,contraindications for special populations,and detoxification protocols was extracted and synthesized.The names of the medicines in the Summary Table were systematically sorted using the first-letter alphabetical order method to construct the framework,enabling the structured presentation of information.Results A total of 119 Chinese patent medicines containing toxic decoction pieces were included.Common ADRs/medication-related injuries primari-ly manifested as gastrointestinal reactions and allergic reactions.Possible severe ADRs/medication-related injuries involved dam-age to the nervous,circulatory,and respiratory systems,as well as hepatorenal dysfunction.The Summary Table achieved systematic integration of ADR/medication-related injury identification,medication contraindication alerts,and emergency management of poi-soning through a categorized organization.Feedback from clinical application indicated that the Summary Table possesses high practical value in enhancing healthcare professionals'confidence in medication use,avoiding irrational drug combinations,and pro-moting rational drug use.Conclusions The Summary Table for the Rational Drug Use of Chinese Patent Medicines Containing Toxic Decoction Pieces,as a clinical auxiliary tool,can effectively improve the safety and rationality of using these medications.It demonstrates good applicability and potential for widespread adoption,although further strengthening the evidence grade and estab-lishing a dynamic updating mechanism are still required.关键词
含毒性饮片的中成药/药品不良反应/药害/特殊人群禁忌/解毒方案Key words
Chinese patent medicines containing toxic decoction pieces/Adverse drug reaction/Medication-related inju-ry/Contraindications in special populations/Detoxification protocol分类
医药卫生
