应用化学2026，Vol.43Issue(4)：617-625,9.DOI:10.19894/j.issn.1000-0518.250334
超临界流体萃取技术在天然产物分离实验中的教学改革实践——以青蒿素绿色提取工艺为例
Teaching Reform Practice of Supercritical Fluid Extraction Technology in Natural Product Separation Experiment:Taking Green Extraction Process of Artemisinin as an Example
摘要
Abstract
As a cornerstone experimental course in applied chemistry,pharmaceutical engineering,and biological science,the natural product separation is pivotal in developing students' practical skills and engineering competencies.This educational reform initiative introduces supercritical fluid extraction(SCFE)technology into the undergraduate curriculum,using artemisinin extraction as a case study to construct a comprehensive,green chemistry-oriented teaching model.The reform features a holistic instructional design-integrating pre-class online modules,in-class hands-on training,and post-class extended tasks-complemented by a multi-dimensional assessment framework.Implementation results demonstrate significant effectiveness:76.4％of students achieved a systematic understanding of SCFE principles and their practical applications;81.3％reported a reinforced grasp of green extraction techniques through direct experimentation;and 68.1％found the open-ended,exploratory tasks markedly enhanced the course's challenge level,effectively stimulating innovative thinking and problem-solving skills.By establishing this integrated teaching paradigm and evaluation system,this study provides a replicable model for greening natural product experiments,with potential to drive the sustainable transformation of laboratory education across related disciplines.关键词
超临界流体萃取/青蒿素/天然产物分离/实验教学改革/绿色化学教育Key words
Supercritical fluid extraction/Artemisinin/Natural product separation/Experimental teaching reform/Green chemistry education分类
化学化工引用本文复制引用
韩海涛,沈广宾,王庆兵..超临界流体萃取技术在天然产物分离实验中的教学改革实践——以青蒿素绿色提取工艺为例[J].应用化学,2026,43(4):617-625,9.基金项目
济宁医学院本科教学改革研究项目(No.yb202418)资助 Supported by the Undergraduate Teaching Reform Research Project of Jining Medical University(No.yb202418) （No.yb202418）
