临床研究2026，Vol.34Issue(4)：59-62,4.DOI:10.12385/j.issn.2096-1278(2026)04-0059-04
不同术式治疗宫颈高级别鳞状上皮内病变的HPV清除效果比较
Comparison of HPV Clearance Effects Between Different Surgical Procedures for High-grade Squamous Intraepithelial Lesions of the Cervix
摘要
Abstract
Objective To compare the human papillomavirus(HPV)clearance effects of cold knife conization(CKC)and total laparoscopic hysterectomy(TLH)in patients with high-grade squamous intraepithelial lesions(HSIL).Methods A total of 200 patients with HSIL who were admitted to Xinxiang Central Hospital between December 2019 and December 2023 were selected as the study subjects.According to the treatment method,they were divided into a CKC group and a TLH group,with 100 patients in each group.The postoperative HPV clearance rate,surgical indicators(operation time,intraoperative blood loss,and length of hospital stay),postoperative follow-up findings(positive surgical margins and residual lesions),and incidence of complications were recorded and analyzed in the two groups.Results There was no statistically significant difference in the HPV clearance rate between the CKC group and the TLH group(P＞0.05).Compared with the TLH group,the CKC group had a shorter operation time and less intraoperative blood loss,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in length of hospital stay between the two groups(P＞0.05).There were no statistically significant differences between the two groups in postoperative positive surgical margins or residual lesions(P＞0.05).There was also no statistically significant difference in the incidence of complications between the two groups(P＞0.05).Conclusion There was no statistically significant difference in the 12-month postoperative HPV clearance rate between CKC and TLH.CKC has advantages in terms of operation time and intraoperative blood loss.There were no statistically significant differences between the two groups in postoperative positive surgical margins,residual lesions,or incidence of complications.In clinical practice,the surgical procedure should be selected individually according to the patient's age,extent of the lesion,follow-up compliance,and coexistence of gynecological diseases.关键词
宫颈冷刀锥切术/腹腔镜全子宫切除术/高级别鳞状上皮内病变/人乳头瘤病毒Key words
cold knife conization/total laparoscopic hysterectomy/high-grade squamous intraepithelial lesion/human papillomavirus引用本文复制引用
陈贝贝,李力,郭祥翠,王倩青..不同术式治疗宫颈高级别鳞状上皮内病变的HPV清除效果比较[J].临床研究,2026,34(4):59-62,4.基金项目
河南省医学科技攻关计划(联合共建)项目(LHGJ20191333). （联合共建）
