湖北医药学院学报2026，Vol.45Issue(2)：158-163,172,7.DOI:10.13819/j.issn.2096-708X.2026.02.006
类风湿关节炎与甲状腺功能障碍之间的孟德尔随机化研究
Relationship Between Rheumatoid Arthritis and Thyroid Dysfunction:A Mendelian Randomization Study
摘要
Abstract
Objective To evaluate the causal relationship between rheumatoid arthritis(RA)and thyroid dysfunction using a Mendelian randomization(MR)approach.Methods Specific single nucleotide polymorphisms(SNPs)associated with RA,hyperthyroidism,and hypothyroidism were selected as instrumental variables.The inverse-variance weighting(IVW)method was used to estimate the reciprocal causal relationship between RA and hyperthyroidism or hypothyroidism.The ro-bustness of the results was tested through sensitivity analysis and pleiotropy tests.Results There was an elevated relative risk of hyperthyroidism(OR=1.33,95％CI=1.17-1.52,P＜0.001)and a heightened risk of hypothyroidism(OR=1.29,95％CI=1.21-1.37,P＜0.001).Conversely,hypothyroidism was also found to increase the relative risk of developing RA(OR=1.57,95％CI=1.30-1.91,P=4.211x10-6).However,the IVW method suggested that there might not be a causal relationship between hyperthyroidism and RA(IVW:P=0.769).Sensitivity analysis showed no pleiotropic effects,confir-ming the reliability of the findings.Conclusion This study demonstrates a bidirectional causal relationship between genetic susceptibility to RA and an increased risk of hypothyroidism,and vice versa.Additionally,there was a positive causal rela-tionship between genetic susceptibility to RA and an elevated risk of hyperthyroidism;however,the study does not provide evidence supporting a causal link between genetic susceptibility to hyperthyroidism and the development of RA.关键词
类风湿关节炎/甲状腺功能亢进/甲状腺功能减退/遗传学/孟德尔随机化Key words
Rheumatoid arthritis/Hyperthyroidism/Hypothyroidism/Genetics/Mendelian randomization引用本文复制引用
孙君阳,汪宇,郑龙..类风湿关节炎与甲状腺功能障碍之间的孟德尔随机化研究[J].湖北医药学院学报,2026,45(2):158-163,172,7.基金项目
湖北省中医药重点项目(ZY2023Z010) （ZY2023Z010）
十堰市太和医院博士科研启动金项目(2024GXL-004) （2024GXL-004）
