中草药2026，Vol.57Issue(9)：3281-3288,8.DOI:10.7501/j.issn.0253-2670.2026.09.003
川楝子中1个新的柠檬苦素型三萜化合物
A novel limonoid-type triterpene from Melia toosendan
摘要
Abstract
Objective To investigate the chemical constituents of limonoid-type triterpenes from the 95%ethanol extract of Melia toosendan and their antitumor activity.Methods The compounds were isolated and purified using various chromatographic techniques,including normal-pressure column chromatography,high-pressure column chromatography,and gel column chromatography.The isolated compounds were structurally characterized by modern spectroscopic techniques.Their antitumor activity was evaluated using the CCK-8 assay.Results Eight limonoid-type triterpenoids were isolated from the ethyl acetate extract of M.toosendan.Structural elucidation by spectroscopic techniques identified them as 15-oxotrichilinin(1),11,15-dioxotrichilinin(2),12-O-ethyl nimbolinin B(3),mufolinoid U(4),trichilinin(5),trichilinin D(6),trichilinin E(7),and trichilinin G(8).Activity evaluation results showed that all compounds exhibited varying degrees of inhibitory effects on four tumor cell lines.Conclusion Compound 1 is a new compound,named 15-oxotrichilinin.Antitumor activity results indicated that compounds 1-8 all possess antitumor activity to varying extents,with some compounds showing favorable activity against HepG2 cells.关键词
川楝子/柠檬苦素型三萜/抗肿瘤活性/川楝子酮/trichilinin/trichilinin GKey words
Melia toosendan Sieb.et Zucc./limonoid-type triterpene/antitumor activity/15-oxotrichilinin/trichilinin/trichilinin G分类
医药卫生引用本文复制引用
杜琳,王琪慧,傅小红,张硕,王芳,杨敏..川楝子中1个新的柠檬苦素型三萜化合物[J].中草药,2026,57(9):3281-3288,8.基金项目
四川省高等学校省级高阶课程项目(2025SJGJKC01) （2025SJGJKC01）
四川省教改项目(JG2024-1131) （JG2024-1131）
