中草药2026，Vol.57Issue(9)：3609-3621,13.DOI:10.7501/j.issn.0253-2670.2026.09.029
中药制药过程中胶束自组装的研究现状及存在挑战
Current status and challenges of micelle self-assembly in traditional Chinese medicine pharmaceutical process
摘要
Abstract
Micelles,formed through the self-assembly of amphiphilic molecules,hold significant promise as drug delivery systems for enhancing the solubility,stability,and targeting properties of active components in traditional Chinese medicine(TCM).Within the field of Chinese medicine formulation,numerous active constituents can spontaneously form micelles or be encapsulated within micellar carriers via specific preparation techniques,thereby effectively improving drug performance.This paper reviews the formation mechanisms,preparation techniques,and current applications of TCM micelles.In view of the hybrid nature of micelles within complex TCM systems,it combines structural characterisation techniques with key influencing factors in micelle formation.The study identifies existing issues such as disordered self-assembly and lack of controllability in current research,proposing corresponding suggestions and future directions.This aims to provide theoretical reference for modernisation of TCM and the development of innovative formulations.关键词
胶束/双亲性分子/自组装/无序性/杂化性/结构表征Key words
micelles/amphiphilic molecules/self-assembly/disorder/hybridity/structural characterisation分类
医药卫生引用本文复制引用
陆琳奕,黄鹿鹿,彭国平,李存玉,支兴蕾..中药制药过程中胶束自组装的研究现状及存在挑战[J].中草药,2026,57(9):3609-3621,13.基金项目
国家自然科学基金资助项目(82274106) （82274106）
中药制药过程控制与智能制造技术全国重点实验室创新项目(NZYSKL240207) （NZYSKL240207）
南京中医药大学中药学一流学科科学研究培育项目(ZYXPY2024-006) （ZYXPY2024-006）
