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Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1-STAT1 interaction

Jingjing Song Jun Tang Pinghuang Liu Changyong Cheng Jin Yuan Rui Zhang Rulan Bai Dongyue Xing Chuang Li Xuan Chen Feiyang Zheng Mingyi Lei Yujin Wang Yuxin Liu

中国病毒学2026,Vol.41Issue(1):132-143,12.
中国病毒学2026,Vol.41Issue(1):132-143,12.DOI:10.1016/j.virs.2026.01.004

Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1-STAT1 interaction

Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1-STAT1 interaction

Jingjing Song 1Jun Tang 1Pinghuang Liu 1Changyong Cheng 2Jin Yuan 3Rui Zhang 1Rulan Bai 1Dongyue Xing 1Chuang Li 1Xuan Chen 1Feiyang Zheng 1Mingyi Lei 1Yujin Wang 1Yuxin Liu1

作者信息

  • 1. State Key Laboratory of Veterinary Public Health and Safety,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China||College of Veterinary Medicine,China Agricultural University,Beijing 100193,China
  • 2. Key Laboratory of Applied Biotechnology on Animal Science & Veterinary Medicine of Zhejiang Province,College of Veterinary Medicine of Zhejiang A&F University,Hangzhou 311300,China
  • 3. College of Animal Science and Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China
  • 折叠

摘要

关键词

Pseudorabies virus(PRV)/Thymidine kinase(TK)/IFN signaling pathway/STAT1/JAK1

Key words

Pseudorabies virus(PRV)/Thymidine kinase(TK)/IFN signaling pathway/STAT1/JAK1

引用本文复制引用

Jingjing Song,Jun Tang,Pinghuang Liu,Changyong Cheng,Jin Yuan,Rui Zhang,Rulan Bai,Dongyue Xing,Chuang Li,Xuan Chen,Feiyang Zheng,Mingyi Lei,Yujin Wang,Yuxin Liu..Pseudorabies virus TK protein antagonizes alpha interferon response by interfering with the JAK1-STAT1 interaction[J].中国病毒学,2026,41(1):132-143,12.

基金项目

This work was supported by the National Natural Science Foundation of China(32172829 and 32192453),the Beijing Municipal Natural Science Foundation(6232026),the State Key Laboratory of Veterinary Public Health and Safety(grant number 2025SKLVPHS07)and the 2115 Talent Development Program of China Agricultural University. (32172829 and 32192453)

中国病毒学

1003-5125

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