首页|期刊导航|中国病毒学|Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus

Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus

Jiawei Xiao Xingyang Guo Xinglin Wang Wei Zhou Hansong Li Feiyu Zhao Li Feng Jialin Zhang Yaru Xu Dan Yang Haixin Liu Donghua Guo Dongbo Sun Xiaoxu Xing Limin Jiang Shanshan Qi Jun Wang Wenfei Bai Shiping Yu Fanbo Shen

中国病毒学2026，Vol.41Issue(1)：208-226,19.

中国病毒学2026，Vol.41Issue(1)：208-226,19.DOI:10.1016/j.virs.2026.02.011

Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus

Jiawei Xiao ¹Xingyang Guo ²Xinglin Wang ²Wei Zhou ²Hansong Li ²Feiyu Zhao ²Li Feng ³Jialin Zhang ⁴Yaru Xu ²Dan Yang ²Haixin Liu ²Donghua Guo ²Dongbo Sun ²Xiaoxu Xing ²Limin Jiang ²Shanshan Qi ²Jun Wang ²Wenfei Bai ²Shiping Yu ²Fanbo Shen²

作者信息

1. College of Animal Science and Veterinary Medicine,Heilongjiang Bayi Agricultural University,Daqing,163319,China||State Key Laboratory for Molecular Biology of Special Economic Animals,Institute of Special Animal and Plant Sciences,Chinese Academy of Agricultural Sciences,Changchun,130112,China
2. College of Animal Science and Veterinary Medicine,Heilongjiang Bayi Agricultural University,Daqing,163319,China
3. State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin,150069,China
4. Fred Hutch Cancer Center,Seattle,WA,98109,USA
折叠

摘要

关键词

Phloretin/Swine enteric coronaviruses/3C-like protease/Broad-spectrum antiviral/Structural modification

Key words

Phloretin/Swine enteric coronaviruses/3C-like protease/Broad-spectrum antiviral/Structural modification

引用本文复制引用

Jiawei Xiao,Xingyang Guo,Xinglin Wang,Wei Zhou,Hansong Li,Feiyu Zhao,Li Feng,Jialin Zhang,Yaru Xu,Dan Yang,Haixin Liu,Donghua Guo,Dongbo Sun,Xiaoxu Xing,Limin Jiang,Shanshan Qi,Jun Wang,Wenfei Bai,Shiping Yu,Fanbo Shen..Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus[J].中国病毒学,2026,41(1):208-226,19.

基金项目

This work was supported by grants from the National Natural Science Foundation of China(grant no.32573354/U23A20236),and the Key Project of Natural Science Foundation of Heilongjiang Province of China(grant no.ZD2023C006). （grant no.32573354/U23A20236）

中国病毒学

ISSN：1003-5125

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