中国病理生理杂志2026，Vol.42Issue(4)：777-784,8.DOI:10.3969/j.issn.1000-4718.2026.04.016
沉默信息调节因子3通过调节线粒体功能影响心血管疾病的研究进展
Role of silent information regulator 3 in mitochondrial function and car-diovascular diseases
摘要
Abstract
Cardiovascular diseases(CVD)remain the leading cause of mortality worldwide.Their complex pathogenesis is closely associated with mitochondrial dysfunction,including impaired energy metabolism,excessive oxida-tive stress,and dysregulated inflammatory responses.Increasing evidence indicates that protein acetylation is a critical post-translational modification governing mitochondrial function.Silent information regulator 3(SIRT3),the most active nicotinamide adenine dinucleotide-dependent deacetylase within the mitochondrial matrix,plays a pivotal role in maintain-ing mitochondrial homeostasis.By deacetylating multiple key mitochondrial proteins,SIRT3 regulates energy metabolism,preserves redox balance,and sustains mitochondrial structural and functional integrity.This review summarizes the molec-ular mechanisms by which SIRT3 modulates mitochondrial structure and function and highlights its involvement in the pathogenesis of major CVD,including hypertension,atherosclerosis,aneurysms,and cardiac hypertrophy.Finally,we discuss the therapeutic potential of targeting SIRT3,providing insights that may facilitate the development of novel strate-gies for the clinical management of cardiovascular diseases.关键词
沉默信息调节因子3/心血管疾病/氧化应激/线粒体/去乙酰化Key words
silent information regulator 3/cardiovascular diseases/oxidative stress/mitochondria/deacetylation分类
医药卫生引用本文复制引用
孔祥敏,朱莲莲,刘雪,朱伟..沉默信息调节因子3通过调节线粒体功能影响心血管疾病的研究进展[J].中国病理生理杂志,2026,42(4):777-784,8.基金项目
国家自然科学基金青年基金项目(No.82300497) （No.82300497）
国家自然科学基金资助项目(No.82370374) （No.82370374）
