中国病理生理杂志2026，Vol.42Issue(4)：792-798,7.DOI:10.3969/j.issn.1000-4718.2026.04.018
SAR1B在囊泡运输与相关疾病中作用的研究进展
Progress in role of SAR1B in vesicle transport and related diseases
摘要
Abstract
The canonical role of secretion-associated Ras-related GTPase 1B(SAR1B)involves the critical regulation of coat protein complex II vesicle formation and budding,as well as the modulation of protein and lipid trans-port.Recent studies have demonstrated that SAR1B also functions as a leucine sensor,modulating the mammalian target of rapamycin complex 1 signaling pathway through leucine-dependent interaction with GTPase-activating protein activity to-ward Rags 2 complex,thereby affecting protein synthesis.In pathological contexts,mutations in SAR1B cause an autoso-mal recessive disorder known as chylomicron retention disease,characterized by fat malabsorption and associated clinical manifestations.Additionally,SAR1B has been implicated in the progression of hepatic and pulmonary tumors and in sus-taining cancer cell survival.This review summarizes the mechanism by which SAR1B promotes vesicle formation and bud-ding,and its multifaceted roles in diverse pathophysiological processes.关键词
分泌关联的Ras相关GTP酶1B/包被蛋白复合体II/脂质代谢/囊性纤维化跨膜传导调节因子/哺乳动物雷帕霉素靶蛋白复合物1Key words
secretion-associated Ras-related GTPase 1B/coat protein complex II/lipid metabolism/cystic fi-brosis transmembrane conductance regulator/mammalian target of rapamycin complex 1分类
医药卫生引用本文复制引用
吴慧雯,戴志强,阳颖,夏志..SAR1B在囊泡运输与相关疾病中作用的研究进展[J].中国病理生理杂志,2026,42(4):792-798,7.基金项目
国家自然科学基金资助项目(No.31960192) （No.31960192）
浙江省自然科学基金资助项目(No.LY23C110001) （No.LY23C110001）
浙江省教育厅科研项目(No.Y202352718) （No.Y202352718）
