中国病理生理杂志2026，Vol.42Issue(4)：813-819,7.DOI:10.3969/j.issn.1000-4718.2026.04.021
泛凋亡分子机制及其在肿瘤治疗中的研究进展
Advances in molecular mechanism of PANoptosis and its application in treatment of tumor
摘要
Abstract
Regulated cell death(RCD)is essential for organismal development,immune responses,and the maintenance of homeostasis.PANoptosis,a recently identified form of RCD,exhibits morphological and molecular fea-tures of apoptosis,pyroptosis,and necroptosis,with complex cross-regulatory mechanisms that dynamically orchestrate physiological balance.Emerging evidence underscores its pivotal role in tumorigenesis by modulating the tumor immune microenvironment,thereby influencing chemotherapy resistance and immune evasion.Understanding the molecular mech-anisms of PANoptosis in tumor progression and identifying key regulatory genes are crucial for advancing insights into this cell death paradigm and its therapeutic potential.This review elucidates the mechanisms underlying PANoptosis initia-tion,assembly,and execution,and summarizes recent advances in targeting PANoptosis signaling pathways for cancer treatment.关键词
泛凋亡/肿瘤/凋亡/焦亡/坏死性凋亡Key words
PANoptosis/tumor/apoptosis/pyroptosis/necroptosis分类
医药卫生引用本文复制引用
王宝烨,康晶..泛凋亡分子机制及其在肿瘤治疗中的研究进展[J].中国病理生理杂志,2026,42(4):813-819,7.基金项目
吉林省自然科学基金面上项目(No.YDZJ202501ZYTS249 （）
No.20210101237JC) （）
国家级大学生创新训练计划(重点领域)项目(No.202413706001) （重点领域）
