中国当代儿科杂志2026，Vol.28Issue(4)：402-409,8.DOI:10.7499/j.issn.1008-8830.2602085
儿童急性白血病治疗格局升级:免疫与靶向的整合与突破
Evolving treatment landscape of pediatric acute leukemia:integration and breakthroughs in immunotherapy and targeted therapy
摘要
Abstract
In recent years,immunotherapy and targeted therapy are reshaping the therapeutic paradigm of pediatric acute leukemia,shifting it from a protocol-driven era toward a strategy-oriented era.The significance is not only in improving remission rates,but also in achieving deeper measurable residual disease(MRD)clearance,enabling more precise risk stratification,reducing cumulative toxicity,and advancing standardized implementation with enhanced accessibility in real-world clinical practice.Integrating pivotal clinical studies,real-world evidence,and advances in drug approval and policy,this article proposes three core themes—deep remission,low toxicity,and high accessibility.It highlights MRD and molecular stratification as anchors for therapeutic decision-making,emphasizes optimizing combination and sequential strategies based on relapse mechanisms,and advocates strengthening long-term follow-up systems and improving access to diagnosis and treatment,aiming to shift clinical practice from efficacy improvement toward high-quality cure.关键词
急性白血病/免疫治疗/靶向治疗/微小残留病/儿童Key words
Acute leukemia/Immunotherapy/Targeted therapy/Measurable residual disease/Child引用本文复制引用
文飞球,麦惠容..儿童急性白血病治疗格局升级:免疫与靶向的整合与突破[J].中国当代儿科杂志,2026,28(4):402-409,8.基金项目
深科技创新(深港合作)项目(2021-254). （深港合作）
