中国当代儿科杂志2026，Vol.28Issue(4)：423-428,6.DOI:10.7499/j.issn.1008-8830.2507065
儿童肿瘤治疗相关重度血小板减少症的现状调查及影响因素分析
Incidence of severe cancer therapy-related thrombocytopenia and associated factors in children
摘要
Abstract
Objective To investigate the incidence of severe cancer therapy-related thrombocytopenia(CTRT)and associated factors in children.Methods A prospective observational study was conducted among 1 047 pediatric inpatients with cancer at Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine from November 2023 to August 2024.Patients were divided into two groups based on the occurrence of severe CTRT.Multivariable logistic regression analysis was used to identify risk factors for severe CTRT.Results Severe CTRT occurred in 343 patients(32.76％).Multivariable logistic regression analysis showed that disease relapse,history of severe CTRT,nutritional risk,use of>3 antineoplastic agents,inclusion of platinum-based agents/cytarabine/anthracyclines in the regimen,and pre-treatment platelet count<100×10 9/L were significantly associated with severe CTRT(P<0.05).Conclusions The incidence of severe CTRT in children is relatively high,and it is influenced by multiple factors including medical history(relapse,previous severe CTRT),treatment regimen(>3 antineoplastic agents,inclusion of platinum-based agents/cytarabine/anthracyclines),and health status(nutritional risk,pre-treatment platelet count<100×109/L).High-risk children should be identified through comprehensive assessment of medical history,health condition,and treatment regimen to provide timely preventive and supportive care.关键词
肿瘤治疗相关重度血小板减少症/危险因素/儿童Key words
Severe cancer therapy-related thrombocytopenia/Risk factor/Child引用本文复制引用
陈琳,沈南平,何梦雪,徐栩婧,孙霁雯,沈碧玉..儿童肿瘤治疗相关重度血小板减少症的现状调查及影响因素分析[J].中国当代儿科杂志,2026,28(4):423-428,6.基金项目
儿联体医院管理科研项目(SHDB-CM-202401) （SHDB-CM-202401）
上海申康医院发展中心临床三年行动计划资助(SHDC2023CRS010). （SHDC2023CRS010）
