中国当代儿科杂志2026，Vol.28Issue(4)：446-451,6.DOI:10.7499/j.issn.1008-8830.2508024
足月适于胎龄儿早发型败血症住院期间不良结局与生后早期体重变化的相关性分析
Association between adverse outcomes during hospitalization and early postnatal weight changes in term appropriate-for-gestational-age infants with early-onset sepsis
曾仕诚 1周娴璐 1向祾祾 1华子瑜1
作者信息
- 1. 重庆医科大学附属儿童医院新生儿科/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿科代谢与炎症性疾病重庆市重点实验室,重庆 400014
- 折叠
摘要
Abstract
Objective To study the association between adverse outcomes during hospitalization and early postnatal weight changes in term appropriate-for-gestational-age(AGA)infants with early-onset sepsis(EOS).Methods A retrospective study was conducted on clinical data of term AGA infants with EOS admitted to the Children's Hospital of Chongqing Medical University from January 2023 to September 2024.The infants were divided into a weight-gain group(weight difference>0 kg;n=229)and a no-weight-gain group(weight difference≤0 kg;n=131)based on the change in weight from birth to postnatal day 7,and the incidence of adverse outcomes during hospitalization was compared between groups.Results Length of hospital stay,duration of antibiotic use,and duration of mechanical ventilation in the weight-gain group were longer than those in the no-weight-gain group(P<0.05).The incidence of acute kidney injury,electrolyte imbalance,intracranial hemorrhage,patent ductus arteriosus,moderate-to-severe pulmonary arterial hypertension,and pulmonary hemorrhage was higher in the weight-gain group than in the no-weight-gain group(P<0.05).Daily net fluid balance on postnatal days 5 and 6,and cumulative net fluid balance on postnatal days 5-7,were higher in the weight-gain group than in the no-weight-gain group(P<0.05).Conclusions Early postnatal weight gain in term AGA infants with EOS is associated with an increased incidence of adverse outcomes during hospitalization,and weight change can serve as one of the indicators to assess neonatal fluid balance.关键词
早发型败血症/适于胎龄儿/体重/液体平衡/足月儿Key words
Early-onset sepsis/Appropriate-for-gestational-age infant/Weight/Fluid balance/Term infant引用本文复制引用
曾仕诚,周娴璐,向祾祾,华子瑜..足月适于胎龄儿早发型败血症住院期间不良结局与生后早期体重变化的相关性分析[J].中国当代儿科杂志,2026,28(4):446-451,6.
