中国防痨杂志2026，Vol.48Issue(5)：677-686,10.DOI:10.19982/j.issn.1000-6621.20260041
基于网络药理学探讨透脓散治疗脓肿型淋巴结结核的作用机制
Mechanism of Tounong San in abscess-type lymph node tuberculosis treatment using network pharmacology
摘要
Abstract
Objective:To explore the underlying molecular mechanism of Tounong San in abscess-type lymph node tuberculosis treatment using network pharmacology.Methods:The active components and potential target of Tounong San were searched and screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).These genes were mapped with the abscess-type lymph node tuberculosis related genes obtained by Genecards and OMIM database,thereby obtaining inter section targets.The String 11.5 database and Cytoscape 3.9.1 software were used to construct the protein-protein interaction(PPI)network and the active ingredient-core target network.Then,gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis of core target genes were carried out by using DAVlD 6.8 platform.Using the DAVID database,we performed intersection target gene ontology functional enrichment analysis and signaling pathway enrichment analysis of the Kyoto gene and genome database.Results:A total of 72 effective drug targets were screened out.Enrichment analysis indicated that the signaling pathways involved in Tounong San in abscess-type lymph node tuberculosis treatment were cell apoptosis and oxidative stress response signaling pathways.AKT1,TP53,ALB and CASP3 might be the key genes in Tounong San-mediated abscess-type lymph node tuberculosis treatment.Conclusion:Tounong San may influence AKT1,TP53,ALB and CASP3 gene expression,to achieve the purpose of treating abscess-type lymph node tuberculosis.关键词
结核,淋巴结/药理作用分子作用机制/透脓散/网络药理学Key words
Tuberculosis,lymph node/Molecular mechanisms of pharmacological action/Tounong San/Network pharmacology分类
医药卫生引用本文复制引用
杨斌,林威兵,赵金凤,程思敏,苗甜甜,王桂荣,曹玉清,宗星煜,王潮虹,赵丽萍,苏达宏,龚蒙萌,马艳,施亦衡..基于网络药理学探讨透脓散治疗脓肿型淋巴结结核的作用机制[J].中国防痨杂志,2026,48(5):677-686,10.基金项目
北京市医疗卫生领域高层次创新创业人才"青苗计划"(G202522153) （G202522153）
北京市通州区科技计划项目(WS2024045) "Young Talent Program"for High-Level Innovative and Entrepreneurial Talents in the Medical and Health Field in Beijing(G202522153) （WS2024045）
Beijing Tongzhou Municipal Science and Technology Commission(WS2024045) （WS2024045）
