中国防痨杂志2026，Vol.48Issue(5)：694-699,6.DOI:10.19982/j.issn.1000-6621.20250466
血液肿瘤患者结核分枝杆菌潜伏感染研究进展
Research progress on latent tuberculosis infection in patients with hematological malignancies
摘要
Abstract
Tuberculosis remains a global public health threat,with latent tuberculosis infection(LTBI)affecting nearly one in four individuals worldwide.While current control efforts appropriately target high-risk populations,LTBI has been extensively characterized in most immunocompromised groups-yet it remains markedly under-investigated in patients with haematological malignancies(HM).The profound immunosuppression intrinsic to the underlying disease,intensified by high-dose cytotoxic chemotherapy and hematopoietic stem-cell transplant conditioning,drives LTBI prevalence in this cohort well above that of the general population.Moreover,LTBI itself is increasingly recognized as an independent contributor to both the incidence and mortality of HM,underscoring the imperative for heightened clinical vigilance.This review synthesizes the contemporary evidence on LTBI in HM patients,providing an evidence-based framework to guide screening,diagnosis,and preventive therapy,and delineates the critical knowledge gaps that continue to impede optimal patient care.关键词
分枝杆菌,结核/感染/血液肿瘤/共病现象/综述Key words
Mycobacterium tuberculosis/Infection/Hematologic neoplasms/Comorbidity/Review分类
医药卫生引用本文复制引用
胡鑫洋,柳阳,高静韬..血液肿瘤患者结核分枝杆菌潜伏感染研究进展[J].中国防痨杂志,2026,48(5):694-699,6.基金项目
Beijing Municipal Health Commission's"High level Public Health Technical Talent Training Plan"(2022-3-015) （2022-3-015）
Tongzhou District"Two High"Talent Plan(YH201903) （YH201903）
Beijing Hospital Management Center's"Climbing the Peak"Talent Training Plan(DFL20221401) 北京市卫生健康委员会"高层次公共卫生技术人才培养计划"(2022-3-015) （DFL20221401）
通州区"两高"人才计划(YH201903) （YH201903）
北京市医院管理中心"登峰"人才培养计划(DFL20221401) （DFL20221401）
