摘要
Abstract
Objective To observe the clinical efficacy of butorphanol combined with flurbiprofen axetil for postoperative analgesia after laparoscopic radical resection of colon cancer.Methods A total of 68 patients undergoing laparoscopic radical resection of colon cancer admitted from February 2023 to February 2025 were prospectively enrolled and randomly divided into the control group and the observation group using the random number table method,with 34 cases in each group.The control group received flurbiprofen axetil for postopera-tive analgesia,while the observation group was given butorphanol combined with flurbiprofen axetil.Mean arte-rial pressure(MAP)and heart rate(HR)were compared at immediately after operation(T1),30 min after operation(T2),1 h after operation(T3),2 h after operation(T4),3 h after operation(T5),and 4 h after operation(T6).Visual Analogue Scale(VAS)pain scores at 6 h,12 h,24 h,and 48 h after operation,blood gas indicators at 30 min after admission to the recovery room,and postoperative adverse reactions were also compared between the two groups.Results MAP and HR in the observation group were significantly higher than those in the control group at T3(P<0.05).VAS scores at 6 h,12 h,and 24 h after operation in the obser-vation group were significantly lower than those in the control group(P<0.05).Partial pressure of carbon dioxide(PaCO₂)and base excess(BE)in the observation group were higher than those in the control group,while partial pressure of arterial oxygen(PaO₂)was significantly lower(P<0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Conclu-sion Butorphanol combined with flurbiprofen axetil shows obvious advantages in postoperative analgesia after laparoscopic radical resection of colon cancer.It can effectively relieve pain,stabilize MAP and HR,reduce the incidence of adverse reactions,and promote postoperative recovery.However,it has certain adverse effects on the blood gas status of patients.Therefore,monitoring of respiratory function should be emphasized in clinical application.关键词
结肠癌/腹腔镜/根治术/布托啡诺/氟比洛芬酯Key words
Colon cancer/Laparoscopy/Radical resection/Butorphanol/Flurbiprofen axetil
