中国康复2026，Vol.41Issue(4)：234-240,7.DOI:10.3870/zgkf.2026.04.008
关节纤维化的病因、发病机制与临床诊疗进展
Advances in the etiology,pathogenesis and clinical management of joint fibrosis
摘要
Abstract
Arthrofibrosis is a pathological condition characterized by excessive fibrous tissue hyperplasia occurring in or around the joint due to various etiological factors,leading to impaired normal joint function.The exact patho-genesis of arthrofibrosis remains incompletely elucidated,encompassing complex processes such as cellular prolifer-ation,activation of fibrogenic signaling pathways,and extracellular matrix remodeling.These processes may be ini-tiated by multiple inciting factors,including trauma,chronic inflammation,immune stress,and metabolic disor-ders.Despite advancements in therapeutic approaches,clinical outcomes for arthrofibrosis remain suboptimal.This review systematically synthesized the major etiological factors,pathological mechanisms,and current treatment mo-dalities for arthrofibrosis,while also delineating future research directions and potential therapeutic strategies to en-hance both scientific research and clinical management of this condition.关键词
关节纤维化/关节挛缩/成纤维细胞Key words
arthrofibrosis/joint contracture/fibroblast分类
医药卫生引用本文复制引用
贾家猛,李薇薇,刘丽美,黄轶欢,潘钰..关节纤维化的病因、发病机制与临床诊疗进展[J].中国康复,2026,41(4):234-240,7.基金项目
国家重点专科建设项目(XKB2023A2001) （XKB2023A2001）
北京市"高创计划·登峰青苗春蕾"项目(G202511047) （G202511047）
