中国临床药理学与治疗学2026，Vol.31Issue(4)：451-459,9.DOI:10.12092/j.issn.1009-2501.2026.04.003
TRPM8与TRPA1基因多态性与中国剖宫产产妇围术期寒战发生的关联性分析
Analysis of the association between TRPM8 and TRPA1 gene poly-morphisms and the occurrence of perioperative shivering in Chinese women undergoing cesarean section
摘要
Abstract
AIM:To explore the impact of TRPM8 and TRPA1 gene polymorphisms on the occurrence of perioperative shivering in Chinese women under-going cesarean delivery and to analyze the risk fac-tors for perioperative shivering.METHODS:A total of 332 Chinese women undergoing cesarean deliv-ery under lumbar anesthesia were enrolled,and the patients'vital signs and potential risk factors for shivering during anesthesia and surgery were recorded.Polymerase chain reaction-restriction fragment length polymorphism analysis was ap-plied to genotype all patients with the gene locus rs1987842,rs2052030,rs7593557,rs1004478,rs13004520,rs10203291 of TRPM8 and the rs3758059,rs10085964,rs28546865,rs9298197,rs959976 gene locus of TRPA1.Finally,logistic re-gression analysis was conducted to assess all poten-tial perioperative shivering risks.RESULTS:The inci-dence of perioperative shivering after single lum-bar anesthesia in 332 women was 48.5%,with a to-tal of 161 cases observed.The results of logistics multifactorial analysis showed that the first cesare-an delivery,operating room temperature below 23 ℃,BMI≤28 kg/m2,SNP locus rs10203291 CC geno-type of TRPM8,and the SNP locus rs9298197 TT genotype of TRPA1 were risk factors for periopera-tive shivering(P<0.05).CONCLUSION:TT genotype of TRPA1 gene rs9298197 and CC genotype of TRPM8 gene rs10203291,first cesarean delivery,operating room temperature below 23 ℃,and BMI less than 28 kg/m2 were risk factors for periopera-tive shivering during cesarean delivery.关键词
剖宫产/寒战/危险因素/TRPM8/TRPA1Key words
cesarean section/shivering/risk fac-tors/TRPM8/TRPA1分类
医药卫生引用本文复制引用
赵珊珊,汪赛赢,段开明,周英勇..TRPM8与TRPA1基因多态性与中国剖宫产产妇围术期寒战发生的关联性分析[J].中国临床药理学与治疗学,2026,31(4):451-459,9.基金项目
国家自然科学基金(82460241) （82460241）
湖南省自然科学基金(2018JJ2598,2025JJ50530) （2018JJ2598,2025JJ50530）
