中国临床药理学与治疗学2026，Vol.31Issue(4)：509-516,8.DOI:10.12092/j.issn.1009-2501.2026.04.010
糖尿病微血管病变中的细胞衰老及治疗药物研究进展
Research progress on cellular senescence and therapeutic drugs in diabetic microvascular complications
摘要
Abstract
Diabetic microangiopathy is the earli-est and most common complication of diabetes mellitus,which is characterised by impaired en-dothelial function of the microvessels,basement membrane thickening and microthrombosis,involv-ing the kidneys,retina and nerves,and it is also a key factor leading to the decline in the patient's quality of life and the shortening of life expectancy.In recent years,clinical and experimental studies have found that cellular senescence is a major risk factor for this type of disease,and cellular senes-cence is an irreversible state of cell cycle arrest,which participates in a variety of physiopathologi-cal processes affecting the occurrence and develop-ment of diabetic microangiopathy.This article pro-vides a review of the mechanism of cellular senes-cence in the process of diabetic microangiopathy and the drugs that target cellular senescence for the treatment of diabetic microangiopathy to pro-vide new research ideas for the prevention and treatment of diabetic microangiopathy.关键词
糖尿病微血管病变/细胞衰老/机制/药物Key words
diabetic microangiopathy/cellular senescence/mechanisms/drugs分类
医药卫生引用本文复制引用
李金菊,杨浩,阮诺冰,许奇,毕正,李瑜璠,王帆竞,林逸轩,方朝晖..糖尿病微血管病变中的细胞衰老及治疗药物研究进展[J].中国临床药理学与治疗学,2026,31(4):509-516,8.基金项目
国家自然科学基金(82174153) （82174153）
合肥综合性国家科学中心大健康研究院"揭榜挂帅"项目(2023CXMMTCM003) （2023CXMMTCM003）
安徽省高校科研项目(2023AH050867) （2023AH050867）
