中国临床药理学与治疗学2026，Vol.31Issue(4)：543-550,8.DOI:10.12092/j.issn.1009-2501.2026.04.014
N6-甲基腺苷修饰调控肿瘤免疫微环境的研究进展
Progress of N6-methyladenosine modification in regulating the tu-mor immune microenvironment
摘要
Abstract
N6-methyladenosine(m6A),as the most prevalent and abundant RNA methylation modification,regulates RNA transcript stabilization,translation efficiency and pre-mRNA splicing and in-fluences several biological processes and plays mul-tiple roles in cancers.The tumor immune microen-vironment consists of a variety of immune cells,cy-tokines,extracellular matrix and other tissue-resi-dent cells that influence tumor growth,metastasis,and drug response.Based on the role of m6A modi-fication in the expression of various immune-relat-ed genes,this review provides a comprehensive un-derstanding of how m6A function in tumor immuni-ty by directly regulating different immune cells as well as indirectly modulating the secretion of im-mune-related factors.关键词
N6-甲基腺苷/肿瘤免疫微环境/免疫细胞/细胞因子/免疫治疗Key words
N6-methyladenosine(m6A)/tumor immune microenvironment/immune cells/cy-tokines/immunotherapy分类
医药卫生引用本文复制引用
张钰,徐文斌,王月琴..N6-甲基腺苷修饰调控肿瘤免疫微环境的研究进展[J].中国临床药理学与治疗学,2026,31(4):543-550,8.基金项目
国家自然科学基金青年项目(81702253) （81702253）
