中国临床药理学与治疗学2026，Vol.31Issue(4)：551-560,10.DOI:10.12092/j.issn.1009-2501.2026.04.015
microRNAs在帕金森病患者中表达谱的变化及诊疗潜力展望
microRNAs expression profile changes in patients with Parkinson's disease and prospects for potential diagnosis and treatment
摘要
Abstract
Parkinson's disease(PD)is an age-as-sociated,slowly progressive extrapyramidal disor-der.Its prevalence is increasing annually in tandem with the aging population in China.The lack of high-ly specific biomarkers poses a significant challenge for the early diagnosis and treatment of PD.microR-NAs(miRNAs),a class of short non-coding RNA molecules,have been found to be dysregulated in the bodily fluids of PD patients and participate in PD pathological processes by regulating endogenous gene expression.The discovery of specific miRNAs expression profiles renders them attractive candi-dates as non-invasive biomarkers and novel thera-peutic targets.This review summarizes research on the relationship between miRNAs dysregulation and PD diagnosis and treatment.It elaborates on recent advancements concerning the roles of miRNAs in PD management by focusing on three key aspects:alterations in expression profiles,diagnostic value,and therapeutic potential.关键词
帕金森病/miRNAs/表达谱/诊断/治疗Key words
Parkinson's disease/miRNAs/expres-sion profile/diagnosis/treatment分类
医药卫生引用本文复制引用
张洁妤,翁伊娜,曹飞..microRNAs在帕金森病患者中表达谱的变化及诊疗潜力展望[J].中国临床药理学与治疗学,2026,31(4):551-560,10.基金项目
国家自然科学基金(82360880) （82360880）
江西省教育厅科学技术研究项目(GJJ2203407) （GJJ2203407）
