中国临床药理学杂志2026，Vol.42Issue(2)：258-264,7.DOI:10.13699/j.cnki.1001-6821.2026.02.018
羟氯喹的临床不良反应研究现状
Research progress on clinical adverse reactions of hydroxychloroquine
摘要
Abstract
As an antimalarial drug,hydroxychloroquine has anti-inflammatory and immunomodulatory effects,and can treat rheumatoid arthritis(RA),systemic lupus erythematosus(SLE)and other diseases.Because of its potential to inhibit virus therapy,it is widely used during the period of novel coronavirus pneumonia.Hydroxychloroquine also has drug side effects,which can cause damage to multiple systems such as the nervous system,cardiovascular system,retina,digestive system,skin,and blood system.Its toxic mechanism is related to Cytochrome P450 3A4(CYP3A4)enzyme metabolism,blocking inward rectifier K+current(IK1),interfering with photoreceptors and retinal pigment epithelial(RPE)cells,and other effects.This study provides a review of the toxic side effects and molecular mechanisms caused by the application of hydroxychloroquine,providing theoretical support for the study of its toxic effects and rational clinical use.关键词
羟氯喹/毒性作用/视网膜/神经系统/心血管系统Key words
hydroxychloroquine/toxic effects/retina/nervous system/cardiovascular system分类
医药卫生引用本文复制引用
刘凡萌,江山,周媛婷,江绍锋,黄金清..羟氯喹的临床不良反应研究现状[J].中国临床药理学杂志,2026,42(2):258-264,7.基金项目
广西自然科学基金资助项目(2025GXNSFHA069125) （2025GXNSFHA069125）
广西肿瘤免疫与微环境调控重点实验室基金资助项目(2024KF011) （2024KF011）
广西高校大学生创新创业计划基金资助项目(S202510601176) （S202510601176）
