中国临床医学2026，Vol.33Issue(2)：203-212,10.DOI:10.12025/j.issn.1008-6358.2026.20251642
侵入式脑机接口电极界面纤维化机制与干预策略进展
Advances in the mechanisms of fibrosis at the electrode interface of invasive brain-computer interfaces and intervention strategies
高奇 1曹晓芳 2贺华 3郑华军4
作者信息
- 1. 上海理工大学健康科学与工程学院,上海 200093||复旦大学上海市生物医药技术研究院,上海 200030
- 2. 上海理工大学健康科学与工程学院,上海 200093||海军军医大学第三附属医院神经外科,上海 200438
- 3. 海军军医大学第三附属医院神经外科,上海 200438
- 4. 复旦大学上海市生物医药技术研究院,上海 200030
- 折叠
摘要
Abstract
The invasive brain-computer interface(BCI)is a method that involves implanting microelectrodes into brain tissue to collect neural electrical signals.The signals obtained through this method are often of high precision and relatively stable.However,the chronic fibrotic reaction resulting from long-term implantation can significantly impair the quality of the collected brain electrical signals.Therefore,ensuring the long-term stability of signal acquisition is a major challenge in the development of invasive BCI.This paper systematically reviews the formation mechanisms of fibrosis at the electrode interface,elaborating on the progression from acute inflammatory responses to the development of chronic glial scars and the formation of the extracellular matrix(ECM).It introduces the roles,advantages,and disadvantages of three anti-fibrosis strategies:material and surface optimization,drug and biological factor intervention,and integration of immune regulation and tissue engineering.This paper also evaluates their practical effects and limitations in animal and human clinical applications.Finally,it highlights the importance of establishment of standardized follow-up recording mechanisms in ensuring the long-term reliability and stability of invasive BCIs,providing references and insights for future in-depth interface optimization and clinical translation.关键词
脑机接口/侵入式电极/纤维化/组织反应/免疫调节Key words
brain-computer interface/invasive electrode/fibrosis/tissue reaction/immunoregulation分类
医药卫生引用本文复制引用
高奇,曹晓芳,贺华,郑华军..侵入式脑机接口电极界面纤维化机制与干预策略进展[J].中国临床医学,2026,33(2):203-212,10.
