中国临床医学2026，Vol.33Issue(2)：285-292,8.DOI:10.12025/j.issn.1008-6358.2026.20251332
慢性肾脏病患者外周血调节性T细胞数量变化及其与血管钙化的相关性
Change in the number of peripheral blood regulatory T cells in patients with chronic kidney disease and its correlation with vascular calcification
摘要
Abstract
Objective To explore the number of peripheral blood regulatory T cells(Treg)in patients with chronic kidney disease(CKD)and its correlation with vascular calcification.Methods This was a single-center,cross-sectional,and observational study.Non-dialysis patients with CKD treated at Zhongshan Hospital,Fudan University from March 2021 to March 2022 were enrolled.Abdominal aortic calcification(AAC)was assessed using lateral abdominal X-ray.Number of Treg and cytokine levels were measured by flow cytometry.Logistic regression analysis was performed to evaluate the related factors for AAC in CKD patients.Results A total of 83 patients were included,aged 17-86 years,with 57 males(68.7%).The distribution of CKD stages was as follows:stage G1 in 7 patients(8.4%),stage G2 in 17 patients(20.5%),stage G3 in 21 patients(25.3%),stage G4 in 19 patients(22.9%),and stage G5 in 19 patients(22.9%).No AAC was observed in patients with stages G1 and G2,while the prevalence of AAC in patients with stages G3,G4,and G5 was 23.8%,21.1%,and 26.3%,respectively.Compared with stage G1 patients,those with stages G3-5 showed decreased number of peripheral blood Treg and elevated levels of interleukin(IL)-6 and IL-17F(P＜0.05).The area under the receiver operating characteristic curve for number of peripheral blood Treg in predicting AAC in CKD patients was 0.766(95%CI 0.652-0.879,P=0.002).Logistic regression analysis showed that decreased number of Treg was related factor for AAC in CKD patients(OR=0.957,95%CI 0.922-0.992,P=0.018).Conclusion As CKD progresses,number of peripheral blood Treg significantly decreases,which is correlated with AAC in CKD patients.关键词
慢性肾脏病/血管钙化/调节性T细胞/细胞因子Key words
chronic kidney disease/vascular calcification/regulatory T cell/cytokine分类
医药卫生引用本文复制引用
张笛,吴蕙,陈静,林丽瑜,龚劭敏,章晓燕,丁小强,张函..慢性肾脏病患者外周血调节性T细胞数量变化及其与血管钙化的相关性[J].中国临床医学,2026,33(2):285-292,8.基金项目
上海市2022年度"科技创新行动计划"医学创新研究专项(22MC1940100).Supported by 2022 STCSM"Science and Technology Innovation Action Plan"Medical Innovation Research Program(22MC1940100). （22MC1940100）
