中国临床医学2026，Vol.33Issue(2)：299-305,7.DOI:10.12025/j.issn.1008-6358.2026.20251490
CT引导下射频消融术作为多发肺结节手术替代方案的疗效与安全性
Efficacy and safety of CT-guided radiofrequency ablation as a surgical alternative for multiple pulmonary nodules
摘要
Abstract
Objective To evaluate the efficacy and safety of CT-guided percutaneous radiofrequency ablation(RFA)as an alternative for video-assisted thoracoscopic surgery(VATS)in treating multiple pulmonary nodules.Methods A retrospective analysis was conducted on the clinical data of 113 patients with multiple pulmonary nodules admitted to Jiangsu Provincial Hospital of Traditional Chinese Medicine from October 2020 to October 2022.The patients were divided into the RFA group(n=50)and the VATS group(n=63)based on the treatment method.Perioperative indicators(operation time,intraoperative blood loss,postoperative length of hospital stay),oncological outcomes(recurrence-free survival[RFS],overall survival[OS]),and postoperative complication rates were compared between the two groups.Univariate and multivariate Cox regression analysis was performed to identify independent prognostic factors.Results The operation time in the RFA group was significantly shorter than that in the VATS group([75.2±20.1]min vs[102.3±28.7])min,P＜0.001).No statistically significant differences were observed in intraoperative blood loss and postoperative length of hospital stay.After follow-up of 24(12,30)months,no statistically significant differences were found in RFS(HR=1.25,P=0.445)or OS(HR=1.42,P=0.402)between the two groups.Mixed ground-glass nodules with high solid component and solid nodule were identified as independent risk factors for RFS(HR=2.44,P=0.023;HR=2.97,P=0.007)and OS(HR=2.87,P=0.022;HR=3.43,P=0.005)in patients with multiple pulmonary nodules.The total complication rate in the RFA group was lower than that in the VATS group(12.0%vs 34.9%,P=0.009).Conclusions The efficacy of CT-guided RFA in treating multiple pulmonary nodules is comparable to that of VATS,with good safety,and it shows promise as an alternative to surgical treatment for multiple pulmonary nodules.关键词
多发肺结节/射频消融/电视辅助胸腔镜手术/替代疗法/微创治疗Key words
multiple pulmonary nodules/radiofrequency ablation/video-assisted thoracoscopic surgery/alternative therapy/minimally invasive treatment分类
医药卫生引用本文复制引用
马长辉,章斌,虞林湘,管仲,杨骏艺,镇海文..CT引导下射频消融术作为多发肺结节手术替代方案的疗效与安全性[J].中国临床医学,2026,33(2):299-305,7.基金项目
江苏省中医药科技发展计划项目(ZD202207).Supported by Traditional Chinese Medicine Science and Technology Development Plan Project of Jiangsu Province(ZD202207). （ZD202207）
