中国临床医学影像杂志2026，Vol.37Issue(4)：285-288,4.DOI:10.12117/jccmi.2026.04.014
超声征象和Ki-67对胆管细胞癌转移的预测及二者的交互作用研究
Predictive value of ultrasound features and Ki-67 expression for cholangiocarcinoma metastasis and their interaction
摘要
Abstract
Objective:To investigate the predictive value of ultrasound features and Ki-67 expression in cholangiocarcinoma metastasis and the interaction between them.Methods:A total of 56 patients diagnosed with cholangiocarcinoma and treated from October 2018 to March 2025 were included in this study.Among them,20 patients had metastatic cholangiocarcinoma,and 36 had non-metastatic cholangiocarcinoma.Clinical data,ultrasound features,and Ki-67 expression were compared be-tween the two groups,and the interaction between ultrasound features and Ki-67 in predicting metastasis was analyzed.Re-sults:Significant differences were observed between the metastasis group and non-metastasis group in terms of TNM stage,e-chogenicity,maximum tumor diameter,tumor morphology,tumor margin,blood flow signal,and Ki-67 expression.Multivariate analysis indicated that TNM stage,echogenicity,maximum tumor diameter,tumor morphology,tumor margin,blood flow signal,and positive Ki-67 expression were all significant risk factors for metastasis.Multiplicative interaction model analysis showed positive interactive effects between Ki-67 and TNM stage,echogenicity,tumor size,morphology,margin,and blood flow sig-nals,jointly influencing the occurrence of metastasis.Conclusion:Ultrasound features and Ki-67 positivity play important roles in the assessment and prediction of cholangiocarcinoma metastasis.Ultrasound can reflect changes in tumor morphology,e-chogenicity,and vascularity,which are associated with tumor proliferative activity and malignancy,aiding in the diagnosis of both primary lesions and metastases.关键词
胆管上皮癌/Ki-67抗原/超声检查Key words
Cholangiocarcinoma/Ki-67 Antigen/Ultrasonography分类
医药卫生引用本文复制引用
王娟娟,侯庆兵,袁中旭,陆启芳,张宏伟..超声征象和Ki-67对胆管细胞癌转移的预测及二者的交互作用研究[J].中国临床医学影像杂志,2026,37(4):285-288,4.基金项目
安徽省卫生健康科研项目(编号:AHWJ2022a003) （编号:AHWJ2022a003）
2024年高等学校省级工程项目(编号2024jyxm1331). （编号2024jyxm1331）
