中国临床药学杂志2026，Vol.35Issue(2)：145-150,6.DOI:10.19577/j.1007-4406.2026.02.008
低白蛋白血症对肺部感染患者替加环素血药浓度、临床疗效及安全性的影响
Impact of hypoalbuminemia on blood concentration,clinical efficacy,and safety of tigecycline in patients with pulmonary infections
摘要
Abstract
AIM To investigate the impact of hypoalbuminemia on blood concentration,clinical efficacy,and adverse reactions of tigecycline(TGC)in patients with pulmonary infections.METHODS A total of 60 patients with pulmonary infections were enrolled and divided into a hypoalbuminemia group(n=29)and a non-hypoalbuminemia group(n=31)based on their serum albumin levels at enrollment.After tigecycline treatment reached a steady state,the total trough blood concentration(Ct,min)and free trough concentration(Cf min)were measured by LC-MS/MS.The clinical efficacy and adverse drug reactions of patients in 2 groups were evaluated at the end of the course of treatment.The Ct,min,Cf,min clinical efficacy rate and the incidence of adverse reactions were compared between 2 groups.RESULTS The Ct,min and Cf min in the hypoalbuminemia group were 201.0(152.0,348.0)ng·mL-1,and 171.0(123.0,303.0)ng·mL-1,respectively,while in the non-hypoalbuminemia group,they were 241.0(155.0,297.0)ng·mL-1 and 173.0(119.0,270.0)ng·mL-1,respectively,with no statistically significant difference between 2 groups(P＞0.05).However,the clinical response rate in the hypoalbuminemia group(55.2％)was significantly lower than that in the non-hypoalbuminemia group(83.9％,P＜0.05).In terms of adverse reactions,the incidence of elevated alkaline phosphatase(34.5％vs 12.9％)and reduced fibrinogen(48.3％vs 16.1％)was significantly higher in the hypoalbuminemia group than in the non-hypoalbuminemia group(P＜0.05),with no significant differences in the incidence of other adverse reactions between 2 groups.CONCLUSION Although the blood concentration of tigecycline is not affected by hypoalbuminemia,it reduces clinical efficacy and increases the risk of adverse reactions.It is recommended to strengthen the monitoring of blood concentration and serum albumin levels in hypoalbuminemia patients using tigecycline to optimize treatment outcomes and reduce adverse reactions.关键词
低白蛋白血症/替加环素/肺部感染/血药浓度Key words
hypoalbuminemia/tigecycline/pulmonary infections/blood concentration分类
医药卫生引用本文复制引用
高培培,黄婉雪,蒋喆,梁培培,杨涛,刘小林,刘彦儒..低白蛋白血症对肺部感染患者替加环素血药浓度、临床疗效及安全性的影响[J].中国临床药学杂志,2026,35(2):145-150,6.基金项目
上海市浦东新区卫生系统优秀青年医学人才培养计划(编号PWRq2022-28) （编号PWRq2022-28）
上海市浦东新区卫生系统重点学科建设项目:临床药学(编号PWZxk2022-27) （编号PWZxk2022-27）
