中国临床药学杂志2026，Vol.35Issue(2)：179-186,8.DOI:10.19577/j.1007-4406.2026.02.016
质谱技术在临床药物体内定量分析中的应用与精准医疗实践进展
Applications of mass spectrometry technology in clinical drug quantitative analysis and precision medicine practices
摘要
Abstract
The process of clinical pharmaceutical quantitative analysis,represented by therapeutic drug monitoring(TDM),serves as a key component of precision medicine.Leveraging high sensitivity,high resolution,and multi-component analysis capabilities,mass spectrometry(MS)is gradually replacing traditional quantitative techniques or serving as an effective supplement to them in specific scenarios,significantly enhancing the accuracy and efficiency of TDM,and emerging as a core tool in clinical pharmaceutical quantitative analysis.In recent years,mass spectrometry technology has undergone rapid development.Beyond traditional triple quadrupole mass spectrometer(QQQ-MS),novel mass spectrometer techniques such as time-of-flight mass spectrometer(TOF-MS),orbitrap mass spectrometer(Orbitrap-MS),inductively coupled plasma mass spectrometer(ICP-MS),matrix-assisted laser desorption/ionization mass spectrometer(MALDI-MS),direct analysis in real-time mass spectrometer(DART-MS),and probe electrospray ionization mass spectrometer(pESI-MS)have emerged.These technologies integrate high throughput,high specificity,and real-time monitoring capabilities,and have become essential supporting technologies in precision medical practice.This review focuses on the principles and applications of the above six types of mass spectrometry technologies,aiming to advance TDM from an experience-driven approach to a data-driven one,thereby providing technical support for personalized medicine.关键词
治疗药物监测/精准医疗/飞行时间质谱/轨道阱质谱/直接实时分析质谱/探针电喷雾电离源质谱/激光解吸电离质谱Key words
therapeutic drug monitoring/precision medicine/time-of-flight mass spectrometer/orbitrap mass spectrometer/direct analysis in real-time mass spectrometer/probe electrospray ionization mass spectrometer/laser desorption/ionization mass spectrometer分类
医药卫生引用本文复制引用
何宇臻,邢云惠,李亚港,伏园园,黄民,朱建雄,钟国平..质谱技术在临床药物体内定量分析中的应用与精准医疗实践进展[J].中国临床药学杂志,2026,35(2):179-186,8.基金项目
国家自然科学基金项目(编号82173776) （编号82173776）
