中国美容医学2026，Vol.35Issue(4)：13-17,5.
硫代牛磺酸抵御皮肤光损伤的作用机制研究
Research on the Mechanisms of Thiotaurine in Protecting Against Photodamage
刘玉晨 1王璐君 1费维成1
作者信息
- 1. 上海辉文生物技术股份有限公司 上海 200120
- 折叠
摘要
Abstract
Objective To explore the repair mechanism of thiotaurine in resisting skin photodamage.Methods A model of light-induced damage was established using keratinocytes and a 3D epidermal model.The study assessed cell viability and Reactive Oxygen Species(ROS)levels post-light damage,as well as tissue vitality,immunofluorescence results for Filaggrin(FLG),Loricrin(LOR),and Lamin-B in the 3D epidermal model,and inflammatory factors.Results It can be known from the light-induced keratinocyte model that thiotaurine can enhance the cell viability after light damage and reduce the production of ROS.The light-induced 3D epidermal model repairs the epidermal barrier by increasing the expression of FLG and LOR,increases the expression of the nuclear senescence marker Lamin-B to resist cellular senescence,and can reduce the secretion of Interleukin-1 alpha(IL-1α)to reduce inflammation.Conclusion Thiotaurine can protect the skin from light-induced damage.关键词
硫代牛磺酸/光损伤/皮肤衰老/皮肤屏障/修护Key words
Thiotaurine/photodamage/skin aging/skin barrier/repair分类
化学化工引用本文复制引用
刘玉晨,王璐君,费维成..硫代牛磺酸抵御皮肤光损伤的作用机制研究[J].中国美容医学,2026,35(4):13-17,5.
