中国美容医学2026，Vol.35Issue(4)：194-198,5.
慢性炎症与皮肤衰老:机制解析及干预策略
Chronic Inflammation and Skin Aging:Mechanism Elucidation and Intervention Strategies
摘要
Abstract
As the outermost barrier of the body,the skin is one of the earliest organs to show changes during the aging process.In recent years,chronic inflammation has been officially listed as one of the core indicators of aging,and the skin is an important site where this inflammatory process occurs.This article systematically reviews the occurrence mechanism of chronic skin inflammation,including factors such as skin cell senescence and its secreted skin-Senescence-Associated Secretory Phenotype(skin-SASP),Skin barrier function impairment,DNA damage,oxidative stress,immunosenescence,microbiota imbalance,and macrophage activation,and clarifies how these factors activate inflammatory pathways,disrupt skin structure and function.Accelerate the aging process of the skin.In addition,this article also explores various intervention strategies from the perspective of anti-inflammation,such as a healthy lifestyle,Senolytics,and stem cell therapy,providing new theoretical basis and practical paths for delaying inflammatory skin aging.In the future,further in-depth research should be conducted on the dynamic change mechanism of skin inflammation to achieve a coordinated intervention of precise inflammation control and effective anti-aging.关键词
皮肤衰老/慢性炎症/抗炎干预/氧化应激/免疫衰老/皮肤微生物Key words
skin aging/chronic inflammation/anti-inflammatory intervention/oxidative stress/immunosenescence/skin microorganisms分类
医药卫生引用本文复制引用
梁颂茹,陈乐宁,陈荣威,叶理,赵平..慢性炎症与皮肤衰老:机制解析及干预策略[J].中国美容医学,2026,35(4):194-198,5.基金项目
广东省普通高校重点领域专项(编号:2025ZDZX4030) （编号:2025ZDZX4030）
广东省大学生创新创业项目(编号:202510573002X,202504302164) （编号:202510573002X,202504302164）
2025年广东省普通高校服务"百千万工程"重点领域项目(编号:G202410573016) （编号:G202410573016）
